Allergic and Immune Disorders: New Insights and Future Directions

Dear Colleagues,

Immunologically driven diseases encompass a broad spectrum of disorders whose prevalence is steadily increasing worldwide. Traditionally, these diseases are classified into three major categories: allergic diseases, inborn errors of immunity (IEI)–formerly known as primary immunodeficiencies–and autoimmune disorders. Although this classification provides a useful framework, in clinical practice the boundaries between these groups are often blurred. These diseases may coexist and share a common underlying mechanism–immune dysregulation, frequently linked to a primary defect in the immune system.

According to the most recent International Union of Immunological Societies (IUIS) classification, Inborn Errors of Immunity currently include 555 distinct disease entities. Despite advances in diagnostic tools, up to 80% of affected individuals remain undiagnosed and are, therefore, not registered in disease databases. Patients often present with an increased susceptibility to infections, autoimmunity, and allergic manifestations. This highlights the importance of a holistic approach to patient care—integrating thorough diagnostic evaluation (including differential diagnosis), optimal nutrition, psychological well-being, and preventive strategies.

The aim of this Special Issue is to gather original, interdisciplinary research focused on the pathophysiology, diagnosis, and therapy of allergic and immunological disorders, with particular emphasis on their overlapping mechanisms and shared pathways. We welcome original research articles, comprehensive reviews, and translational studies that broaden our understanding of immune-mediated diseases and contribute to the development of innovative diagnostic and therapeutic approaches.

Potential topics include, but are not limited to, the following:

• Molecular and cellular mechanisms of allergic and immunodeficiency disorders;
• Immunomodulation and innovative experimental therapies;
• The role of the microbiome and environmental factors in immune regulation and allergic disease;
• Novel biomarkers of immunonutrition;
• Dietary and nutritional strategies in autoimmune and allergic diseases;
• Holistic patient care in allergy and immune-mediated disorders;

Prof. Dr. Krzysztof Pałgan
Guest Editor

Dr. Katarzyna Napiórkowska-Baran
Guest Editor Assistant

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• allergy
• immunology
• clinical immunology
• asthma
• diagnosis
• treatment
• management
• precision medicine