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Medicina
Special Issues
Early Lung Cancer: Diagnosis and Treatment
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Early Lung Cancer: Diagnosis and Treatment

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Pulmonology".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 6458

Special Issue Editors

Dr. Takahiro Homma

E-Mail Website
Guest Editor
Department of Thoracic Surgery, St. Marianna University School of Medicine, Kawasaki, Japan
Interests: minimally invasive surgery; ERAS; surgical education; uniportal VATS; uniportal RATS; energy device; perioperative management
Special Issues, Collections and Topics in MDPI journals
Dr. Hideki Marushima

E-Mail Website
Guest Editor
Department of Chest Surgery, St. Marianna University School of Medicine, Kawasaki, Japan
Interests: lung cancer; thoracic disease

Special Issue Information

Dear Colleagues,

The widespread use of CT scans has revolutionized the early detection of lung cancer. This shift has not only led to a paradigm change in treatment approaches—from traditional lobectomy to segmentectomy or partial resection—but also witnessed advancements in high-performance radiotherapy techniques.

Our Special Issue aims to comprehensively explore various facets of early-stage lung cancer. From diagnostics to surgical and radiotherapeutic interventions, we seek to delve into topics such as treatment modalities, extent of lung resections, surgical approaches and intraoperative techniques for identifying small lung cancers.

The Special Issue will feature cutting-edge research, highlighting the latest advancements in the diagnosis and treatment of early-stage lung cancer. From innovative diagnostic tools to state-of-the-art surgical and radiotherapy technologies, we aim to showcase the forefront of scientific progress in this field.

We invite submissions covering a broad spectrum of themes related to early-stage lung cancer, including, but not limited to, diagnostic methods, medical checkup, surgical and radiotherapeutic therapy, extent of lung resection, intraoperative identification of small lung cancers. Researchers and practitioners are encouraged to contribute their insights to advance our understanding and treatment of this critical health issue.

Dr. Takahiro Homma
Dr. Hideki Marushima
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • lung cancer
  • diagnosis
  • thoracic surgery
  • robot-assisted thoracoscopic surgery
  • video-assisted thoracoscopic surgery
  • lung resection
  • segmentectomy
  • radiation therapy
  • navigation
  • computed tomography

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Published Papers (3 papers)

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Research

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11 pages, 1831 KB  
Article
Feasibility and Safety of Uniportal Thoracoscopic Segmentectomy Using a Unidirectional Dissection Approach without Dissecting a Fissure
by Hitoshi Igai, Mitsuhiro Kamiyoshihara, Kazuki Numajiri, Fumi Ohsawa and Kazuhito Nii
Medicina 2024, 60(6), 994; https://doi.org/10.3390/medicina60060994 - 17 Jun 2024
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Abstract
Background: Few original articles describe the perioperative outcomes of uniportal thoracoscopic segmentectomy using a unidirectional dissection approach. In this retrospective study, we evaluated the feasibility and safety of this procedure. Methods: This study included 119 patients who underwent uniportal thoracoscopic segmentectomy [...] Read more.
Background: Few original articles describe the perioperative outcomes of uniportal thoracoscopic segmentectomy using a unidirectional dissection approach. In this retrospective study, we evaluated the feasibility and safety of this procedure. Methods: This study included 119 patients who underwent uniportal thoracoscopic segmentectomy in our department between February 2019 and December 2022. The patients were divided into unidirectional (group U, n = 28) and conventional (group C, n = 91) dissection approach groups. While the dominant pulmonary vessels and bronchi were transected at the hilum without dissecting a fissure in the unidirectional (U) group, the dominant pulmonary artery was exposed and divided at a fissure in the conventional (C) group. Patient characteristics and perioperative outcomes were compared between groups U and C. Results: The proportions of simple and complex segmentectomies were statistically similar between the groups. The operating time was shorter (group U: 110 [interqurtile range: 90–140] min, group C: 135 [interqurtile range: 105–166] min, p = 0.012) and there was less blood loss (group U: 0 [interqurtile range: 0–0] g, group C: 0 [interqurtile range: 0–50] g, p = 0.003) in group U than in group C. However, there were no significant intergroup differences in other perioperative outcomes. Conclusions: The unidirectional dissection approach in uniportal thoracoscopic pulmonary segmentectomy is safe and feasible and enables a smoother operation. Full article
(This article belongs to the Special Issue Early Lung Cancer: Diagnosis and Treatment)
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12 pages, 3727 KB  
Article
Correlation between Radiological Characteristics, PET-CT and Histological Subtypes of Primary Lung Adenocarcinoma—A 102 Case Series Analysis
by Nikola Colic, Ruza Stevic, Mihailo Stjepanovic, Milan Savić, Jelena Jankovic, Slobodan Belic, Jelena Petrovic, Nikola Bogosavljevic, Dejan Aleksandric, Katarina Lukic, Marko Kostić, Dusan Saponjski, Jelena Vasic Madzarevic, Stefan Stojkovic, Maja Ercegovac and Zeljko Garabinovic
Medicina 2024, 60(4), 617; https://doi.org/10.3390/medicina60040617 - 10 Apr 2024
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Abstract
Background and Objectives: Lung cancer is the second most common form of cancer in the world for both men and women as well as the most common cause of cancer-related deaths worldwide. The aim of this study is to summarize the radiological characteristics [...] Read more.
Background and Objectives: Lung cancer is the second most common form of cancer in the world for both men and women as well as the most common cause of cancer-related deaths worldwide. The aim of this study is to summarize the radiological characteristics between primary lung adenocarcinoma subtypes and to correlate them with FDG uptake on PET-CT. Materials and Methods: This retrospective study included 102 patients with pathohistologically confirmed lung adenocarcinoma. A PET-CT examination was performed on some of the patients and the values of SUVmax were also correlated with the histological and morphological characteristics of the masses in the lungs. Results: The results of this analysis showed that the mean size of AIS-MIA (adenocarcinoma in situ and minimally invasive adenocarcinoma) cancer was significantly lower than for all other cancer types, while the mean size of the acinar cancer was smaller than in the solid type of cancer. Metastases were significantly more frequent in solid adenocarcinoma than in acinar, lepidic, and AIS-MIA cancer subtypes. The maximum standardized FDG uptake was significantly lower in AIS-MIA than in all other cancer types and in the acinar predominant subtype compared to solid cancer. Papillary predominant adenocarcinoma had higher odds of developing contralateral lymph node involvement compared to other types. Solid adenocarcinoma was associated with higher odds of having metastases and with higher SUVmax. AIS-MIA was associated with lower odds of one unit increase in tumor size and ipsilateral lymph node involvement. Conclusions: The correlation between histopathological and radiological findings is crucial for accurate diagnosis and staging. By integrating both sets of data, clinicians can enhance diagnostic accuracy and determine the optimal treatment plan. Full article
(This article belongs to the Special Issue Early Lung Cancer: Diagnosis and Treatment)
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Other

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10 pages, 4253 KB  
Case Report
Two Different Tumors and Lung Aspergilloma: An Uncommon Etiopathogenic Association
by Vlad Alexandru Ionescu, Gina Gheorghe, Cosmin Adrian, Alexandru Bebliuc, Cezar Pavelescu, Valentin Enache, Florentina Gheorghe, Nicolae Bacalbasa and Camelia Cristina Diaconu
Medicina 2024, 60(6), 953; https://doi.org/10.3390/medicina60060953 - 7 Jun 2024
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Abstract
Several cases reported in the literature have confirmed the link between pulmonary aspergillosis and various malignant diseases. Furthermore, it has been observed that the correlation between carcinoid tumor and lung adenocarcinoma is quite uncommon. The etiopathogenic mechanisms underlying these correlations remain poorly defined. [...] Read more.
Several cases reported in the literature have confirmed the link between pulmonary aspergillosis and various malignant diseases. Furthermore, it has been observed that the correlation between carcinoid tumor and lung adenocarcinoma is quite uncommon. The etiopathogenic mechanisms underlying these correlations remain poorly defined. We present the case of a patient with three of these diseases: a lung adenocarcinoma with a lepidic pattern, a typical carcinoid, and pulmonary aspergillosis. An additional noteworthy aspect of this case pertains to the timely detection of both lung malignancies. Thus, the necessity for further investigation to ascertain the pathogenic connection among the three diseases is underscored. The ultimate objective is to enhance the prognosis of individuals diagnosed with lung cancer, which is a prevailing malignant disease on a global scale. Full article
(This article belongs to the Special Issue Early Lung Cancer: Diagnosis and Treatment)
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