Updates on Spleen Diseases and Splenectomy

A special issue of Medicina (ISSN 1648-9144).

Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 320

Special Issue Editor


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Guest Editor
Department of Surgery of the School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Interests: spleen; splenectomy; portal hypertension; appendicitis; wound healing; digestive motility; peptic ulcer; digestive oncological surgery; ethics; education

Special Issue Information

Dear Colleagues,

The spleen is one of the most important organs and is responsible for many essential functions, such as the defense of organisms, the removal of foreign particles, bacteria, viruses, fungi and parasites from the blood flow, the metabolism of bilirubins, lipids and several aminoacids, the control of the number of blood leukocytes and platelets, the maturity of lymphocytes and opsonins, haematopoesis, among others. Thus, this organ belongs to several medical specialties, mainly haematology, immunology, oncology, infectology and surgery.

Splenectomy is most commonly used in trauma, but it is also performed to treat haematological, immunological, metabolic and oncological diseases. Other indications for splenectomy include morphological disturbances, retarded somatic and sexual development, portal hypertension, parasitic infections, abscesses, haemangiomas and cysts. Until recently, the absence of the spleen was not considered as a risk factor for severe complications, even with the knowledge of death provoked by postsplenectomy sepsis, which has been described since the nineteenth century. However, many studies have proved that the complete removal of the spleen is mostly useless, and is followed by a high rate of precocious mortality, due to overwhelming sepsis, meningitis, pneumonia, pulmonary thromboembolism, liver failure, and most of patients loose completely their libido.

Haematological diseases, such as myeloid hepatosplenomegaly, leukemias and lymphomas, as well as metabolic affections, including dyslipidemias, are followed by high morbidity and mortality rates when the spleen is removed. Conservative surgeries, including partial splenectomy, subtotal splenectomy and splenic tissue autotransplantation, are recommended to avoid the many complications and deaths as result of the asplenic state.

This Special Issue of the prestigious journal “Medicina” is dedicated to all aspects of the spleen in clinical and surgical practice. The authors will contribute advances in the spleen knowledge. Following the latest scientific advances, the spleen is no longer as mysterious as it was described by Claudius Galen in the first century of this era.

Prof. Dr. Andy Petroianu
Guest Editor

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Keywords

  • spleen
  • splenectomy
  • asplenic state
  • partial splenectomy
  • subtotal splenectomy
  • splenic autotransplantation
  • overwhelming sepsis
  • pulmonary thromboembolism
  • splenic blood clearance
  • spleen updates

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Published Papers

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