New Insights into Diabetes Complications—Diabetic Foot

Dear Colleagues,

Diabetic foot remains one of the most severe and challenging complications of diabetes mellitus, representing a leading cause of hospitalization, disability, and non-traumatic lower limb amputation worldwide. Since the early recognition of diabetic neuropathy and ischemia as key pathogenic factors, decades of research have deepened our understanding of the molecular, vascular, and biomechanical mechanisms contributing to foot ulceration and impaired wound healing. Despite advances in glycemic control and multidisciplinary care, the global burden of diabetic foot disease continues to rise, underscoring the urgent need for innovative diagnostic, preventive, and therapeutic strategies.

The aim of this Special Issue, New Insights into Diabetes Complications—Diabetic Foot, is to provide a comprehensive platform for state-of-the-art research addressing the complex interplay of factors that underlie diabetic foot development and progression. We seek to highlight novel mechanisms, emerging technologies, and clinical practices that can transform patient outcomes and reduce the socioeconomic impact of this devastating condition.

We particularly welcome cutting-edge studies that explore molecular pathways of tissue damage, biomarkers for early detection, advanced imaging techniques, regenerative therapies, bioengineered dressings, and artificial intelligence-driven tools for risk stratification and wound management. Multidisciplinary and translational research, as well as systematic reviews and meta-analyses that synthesize current evidence, are also encouraged.

We invite original research articles, comprehensive reviews, and clinical studies that contribute to a deeper understanding of diabetic foot pathology and its prevention. Through this Special Issue, we aim to foster collaboration among researchers, clinicians, and technologists to pave the way toward more personalized and effective care for individuals with diabetes.

Dr. Álvaro Astasio Picado
Dr. Enrico Brocco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• diabetic foot
• diabetes complications
• neuropathy
• peripheral arterial disease
• wound healing
• ulceration
• infection
• biomarkers
• regenerative medicine
• tissue engineering
• inflammation
• microcirculation
• artificial intelligence
• predictive modeling
• precision medicine
• preventive care
• multidisciplinary management
• amputation prevention
• translational research
• emerging therapies