Craniomaxillofacial Surgery 4.0: Personalized Digital Planning, Augmented Reality, Point-of-Care Manufacturing and Molecular Data Integration
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dentistry and Oral Health".
Deadline for manuscript submissions: 20 January 2026 | Viewed by 47
Special Issue Editors
Interests: rare jaw tumors; CCOC; minimally invasive surgery; tissue engineering
Interests: craniomaxillofacial surgery; 3D printing; point-of-care manufacturing; microsurgery; reconstructive surgery; head and neck oncology
Special Issue Information
Dear Colleagues,
Craniomaxillofacial surgery has undergone a significant transformation in recent years, especially in the post-COVID era, driven by the rapid adoption of digital and personalized technologies. Originating from the broader concept of Industry 4.0, the term “Surgery 4.0” reflects the integration of technologies such as additive manufacturing, augmented and virtual reality, artificial intelligence, and multi-omics data into surgical workflows. In craniomaxillofacial surgery, these innovations have begun to reshape the way complex reconstructions, oncologic rehabilitations, and deformity corrections are approached, enabling more precise, efficient, and individualized treatments.
This Special Issue aims to explore and disseminate the most recent and impactful advancements in Craniomaxillofacial Surgery 4.0. It will focus on how digital planning, point-of-care manufacturing, advanced visualization technologies, and molecular data integration are revolutionizing the field. It will collate contributions from clinicians, biomedical engineers, data scientists, and other stakeholders who are pioneering the use of these tools to improve surgical outcomes. The scope covers both clinical and translational research, including technological development, case series, workflow innovation, and patient-centered approaches.
We are particularly interested in contributions that address the following topics:
- Point-of-care manufacturing of patient-specific implants and surgical guides;
- Integration of 3D printing into preoperative planning and intraoperative navigation;
- Applications of augmented, virtual, and mixed reality in reconstructive and orthognathic surgery;
- Implant-guided rehabilitation strategies in oncologic maxillofacial patients;
- Smart surgical instruments (SSIs) and real-time intraoperative feedback systems;
- Omics-based approaches for surgical planning and tumor stratification;
- AI-based surgical planning, decision support systems, and data analytics.
We welcome a wide range of manuscript types including but not limited to the following:
- Original research articles;
- Clinical case series with technological integration;
- Reviews and meta-analyses;
- Translational research bridging technology and clinical practice;
- Perspective and opinion pieces from experts in the field.
The goal is to provide a comprehensive and multidisciplinary overview of how Craniomaxillofacial Surgery 4.0 is shaping the future of patient care.
Dr. Maria J. Troulis
Guest Editor
Dr. Manuel Tousidonis
Guest Editor Assistant
Manuscript Submission Information
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Keywords
- craniomaxillofacial surgery
- 3D printing
- point-of-care manufacturing
- microsurgery
- reconstructive surgery
- head and neck oncolog
- rare jaw tumors
- CCOC
- minimally invasive surgery
- tissue engineering
- personalized digital planning
- augmented reality
- molecular data integration
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