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Marine Drugs
Special Issues
Marine Drugs Studies in China
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Marine Drugs Studies in China

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (31 January 2009) | Viewed by 40355

Special Issue Editors

Dr. Shu-Kun Lin

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Managing Editor
MDPI, St. Alban-Anlage 66, CH-4052 Basel, Switzerland
Interests: gibbs paradox; entropy; symmetry; similarity; diversity; information theory; thermodynamics; process irreversibility or spontaneity; stability; nature of the chemical processes; molecular recognition; open access journals
Ms. Tina Wang

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Assistant Editor
MDPI Tongzhou Office, Room 2207, Jincheng Center, No. 21 Cuijingbeili, Tongzhou District, Beijing 101101, China

Keywords

  • marine drugs related research in the P. R. China

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Published Papers (2 papers)

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Research

10 pages, 278 KiB  
Article
Protective Effects of Squid Ink Extract Towards Hemopoietic Injuries Induced by Cyclophosphamine
by Jie-Ping Zhong, Guang Wang, Jiang-Hua Shang, Jiang-Qiu Pan, Kun Li, Yan Huang and Hua-Zhong Liu
Mar. Drugs 2009, 7(1), 9-18; https://doi.org/10.3390/md7010009 - 14 Jan 2009
Cited by 47 | Viewed by 14136
Abstract
To investigate the protective effects of squid ink in chemotherapy, BALB/c mice were used as animal models of injuries induced by cyclophosphamine, a well known chemotherapeutic drug. The mice were randomly divided into five groups with the same number of males and females [...] Read more.
To investigate the protective effects of squid ink in chemotherapy, BALB/c mice were used as animal models of injuries induced by cyclophosphamine, a well known chemotherapeutic drug. The mice were randomly divided into five groups with the same number of males and females in each group. At the end of the experiment, animals were sacrificed to investigate organ indexes and antioxidant ability of the spleen, peripheral blood profile and quantities of bone marrow nucleated cells. Results showed that the hemopoietic function of mice was injured by cyclophosphamine, as indicated by decreases of contents of erythrocytes, leukocytes, hemoglobin and bone marrow nucleated cells (P<0.01), while platelets were not affected (P>0.05), as well as modification of organ indexes (P<0.05) and spleen antioxidant ability (P<0.05 or P<0.01), whereas sepia extract markedly increased the levels of erythrocytes, leukocytes, hemoglobin and bone marrow nucleated cells (P<0.01), but not platelets (P>0.05), and reversed the effects of cyclophosphamine on organ indexes and antioxidant ability of spleen (P<0.01 or P<0.05). In addition, squid ink extract did not change marrow hemopoiesis but improved the antioxidant ability of spleen in the animals. The data suggest that squid ink extract can protect the hemopoietic system from chemotherapeutic injury and could be employed to develop cell-protective drugs for use in clinical treatment of tumours. Full article
(This article belongs to the Special Issue Marine Drugs Studies in China)
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21 pages, 542 KiB  
Article
Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China
by Kui Hong, An-Hui Gao, Qing-Yi Xie, Hao Gao Gao, Ling Zhuang, Hai-Peng Lin, Hai-Ping Yu, Jia Li, Xin-Sheng Yao, Michael Goodfellow and Ji-Sheng Ruan
Mar. Drugs 2009, 7(1), 24-44; https://doi.org/10.3390/md7010024 - 3 Jan 2009
Cited by 313 | Viewed by 25398 | Correction
Abstract
The mangrove ecosystem is a largely unexplored source for actinomycetes with the potential to produce biologically active secondary metabolites. Consequently, we set out to isolate, characterize and screen actinomycetes from soil and plant material collected from eight mangrove sites in China. Over 2,000 [...] Read more.
The mangrove ecosystem is a largely unexplored source for actinomycetes with the potential to produce biologically active secondary metabolites. Consequently, we set out to isolate, characterize and screen actinomycetes from soil and plant material collected from eight mangrove sites in China. Over 2,000 actinomycetes were isolated and of these approximately 20%, 5%, and 10% inhibited the growth of Human Colon Tumor 116 cells, Candida albicans and Staphylococcus aureus, respectively, while 3% inhibited protein tyrosine phosphatase 1B (PTP1B), a protein related to diabetes. In addition, nine isolates inhibited aurora kinase A, an anti-cancer related protein, and three inhibited caspase 3, a protein related to neurodegenerative diseases. Representative bioactive isolates were characterized using genotypic and phenotypic procedures and classified to thirteen genera, notably to the genera Micromonospora and Streptomyces. Actinomycetes showing cytotoxic activity were assigned to seven genera whereas only Micromonospora and Streptomyces strains showed anti-PTP1B activity. We conclude that actinomycetes isolated from mangrove habitats are a potentially rich source for the discovery of anti-infection and anti-tumor compounds, and of agents for treating neurodegenerative diseases and diabetes. Full article
(This article belongs to the Special Issue Marine Drugs Studies in China)
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