Marine Antiparasitic Agent

A special issue of Marine Drugs (ISSN 1660-3397).

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 4392

Special Issue Editors

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Guest Editor
Instituto Universitario de Bio-Orgáncia Antonio González (IUBOAG), Universidad de la Laguna (ULL), 38206 San Cristobal de La Laguna, Spain
Interests: marine natural products; marine toxins; marine polyether; marine microalgae; biosynthesis; Laurencia; antiparasitic substances; phosphatase inhibitors
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Guest Editor
Instituto de Productos Naturales y Agrobiología (IPNA), Consejo Superior de Investigaciones Científicas (CSIC), Avenida Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain
Interests: marine natural products; marine microbial compounds; bioassay-guided isolation; NMR structural analysis; biomedical applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Parasitic diseases are common worldwide. Their incidence increases in tropical and subtropical areas where these infections are an expanding problem. In recent decades, efforts have intensified in the search for new molecules with antiparasitic activity as alternatives with reduced side effects and that can be used in cases where parasites develop resistance to commercial therapeutic drugs. Recently, molecules of marine origin have begun to be a source of inspiration to numerous multidisciplinary laboratories for the development of these antiparasitic therapies.

Accordingly, the aim of this Marine Drugs Special Issue is to cover new findings on the potential therapeutic activity of natural molecules obtained from marine sources or active compounds produced by synthesis, highlighting novel structural features, bioactivities, and mechanisms of action with respect to antiparasitic activity. Review articles that make substantial advances within this field will also be considered.

As Guest Editors of this Special Issue of Marine Drugs, we encourage scientists working in any field involving marine antiparasitic exploration, new natural molecules with these biological activities, or industrial applications to contribute details of their recent research activity as this may lead to further significant advances in this area.

Prof. Dr. José Javier Fernández Castro
Dr. Ana R. Díaz-Marrero
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • bioactive compound
  • antiparasitic
  • antiprotozoal
  • helminthic
  • amoebas

Published Papers (1 paper)

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21 pages, 3155 KiB  
Targeted Isolation of Anti-Trypanosomal Naphthofuran-Quinone Compounds from the Mangrove Plant Avicennia lanata
by Noor Wini Mazlan, Carol Clements and RuAngelie Edrada-Ebel
Mar. Drugs 2020, 18(12), 661; - 21 Dec 2020
Cited by 7 | Viewed by 3653
The discovery of new secondary metabolites from natural origins has become more challenging in natural products research. Different approaches have been applied to target the isolation of new bioactive metabolites from plant extracts. In this study, bioactive natural products were isolated from the [...] Read more.
The discovery of new secondary metabolites from natural origins has become more challenging in natural products research. Different approaches have been applied to target the isolation of new bioactive metabolites from plant extracts. In this study, bioactive natural products were isolated from the crude organic extract of the mangrove plant Avicennia lanata collected from the east coast of Peninsular Malaysia in the Setiu Wetlands, Terengganu, using HRESI-LCMS-based metabolomics-guided isolation and fractionation. Isolation work on the crude extract A. lanata used high-throughput chromatographic techniques to give two new naphthofuranquinone derivatives, hydroxyavicenol C (1) and glycosemiquinone (2), along with the known compounds avicenol C (3), avicequinone C (4), glycoquinone (5), taraxerone (6), taraxerol (7), β-sitosterol (8) and stigmasterol (9). The elucidation and identification of the targeted bioactive compounds used 1D and 2D-NMR and mass spectrometry. Except for 6–9, all isolated naphthoquinone compounds (1–5) from the mangrove plant A. lanata showed significant anti-trypanosomal activity on Trypanosoma brucei brucei with MIC values of 3.12–12.5 μM. Preliminary cytotoxicity screening against normal prostate cells (PNT2A) was also performed. All compounds exhibited low cytotoxicity, with compounds 3 and 4 showing moderate cytotoxicity of 78.3% and 68.6% of the control values at 100 μg/mL, respectively. Full article
(This article belongs to the Special Issue Marine Antiparasitic Agent)
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