Analysis of Marine Natural Products Using Hyphenated Techniques
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 6529
Special Issue Editor
Interests: chromatography; mass spectrometry; liquid chromatography; natural product chemistry; nuclear magnetic resonance; bioactivity; medicinal chemistry; NMR structure elucidation; LC-MS/MS; MIC; compound isolation; structure elucidation; natural products; metabolite identification; alkaloids; pharmacognosy; bioassays; HPLC-UV; bioactive secondary metabolites; marine natural products
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Special Issue Information
Hyphenated techniques in the context of natural product chemistry refer to the coupling of a chromatographic and a spectral/spectroscopic technique for the analysis of extracts or complex mixtures of natural compounds. Recent advances in this field, mainly associated with the development of ultra-fast HPLC separation equipment and last generation mass spectrometry and NMR instruments have remarkably widened the use of these techniques in the marine natural products field. The development of algorithms and platforms for the analysis of data originated from these sources, such as the Global Natural Products Social molecular networking (GNPS) or the Small Molecular Accurate Recognition Technology (SMART) has notably enhanced the efficient exchange of data, establishing a community of users, and allowing the propagation of information that eventually can lead to the discovery of new bioactive molecules. Chemical dereplication, chemotaxonomic studies, chemical finger-printing, metabolomic studies, molecular networking, microbial community interactions, biosynthetic pathways, partial identification of compounds, and isolation of bioactive natural products constitute specific examples of tasks that can be successfully accomplished using these techniques and platforms. This Special Issue is intended as a comprehensive recompilation of articles that cover the application of hyphenated techniques and their associated platforms in all the aspects referred to above, in the context of marine research, with a special focus on applications related to the discovery of new marine bioactive compounds.
Dr. Fernando Reyes
Guest Editor
Manuscript Submission Information
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Keywords
- Hyphenated techniques
- LC/MS
- LC/NMR
- Marine natural products
- Bioactive compounds
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