Recent Advances in Marine-Derived Pigments

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 870

Special Issue Editors

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Guest Editor
Littoral Environnement et Sociétés UMRi CNRS 7266 LIENSs, La Rochelle Université, 17042 La Rochelle, France
Interests: anticancer compounds; heterocycles; melanoma; microalgae; natural products; pharmacology; pigments; tumor phototherapy
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Guest Editor
UMR 8038 CiTCoM, Faculté de Santé, UFR Pharmacie, Université Paris Cité, 75006 Paris, France
Interests: marine natural products; anticancer; pigments; microalgae; chemosensitization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Marine pigments are critical as prospective drug candidates because they possess unique chemical structures and biological activities that award them high therapeutic potential. Many marine organisms produce pigments in order to perform photosynthesis, photoprotection, phototropism and provide natural defense mechanisms against predators and environmental stressors. Beyond the classical biological activities that have been reported for marine pigments, such as their antioxidant, anti-inflammatory, cytotoxic, pro-apoptotic, and antimicrobial properties, their novel and innovative uses are now being considered; indeed, they possess the potential to provide phototoxicity to pathogenic microorganisms and tumor cells, antiviral activity, sensitization to chemotherapy and radiation therapy, and immunomodulation.

The objective of this Special Issue is to highlight the latest developments in marine pigment research, including chemical diversity within marine taxa, chemical ecology studies aimed at understanding the natural function of these bioactive compounds, innovations in extraction, purification, and structural elucidation, as well as biotechnological and pharmaceutical developments. Pharmacological studies that highlight the novel modes of action in marine pigments at the cellular or molecular level will also be considered.

For this Special Issue, we invite scientists from both academia and industry to submit original and conceptual analyses and research papers that emphasize the potential of marine pigments as innovative marine drugs and molecules of biotechnological interest. We thank you for your contribution to the success of this Special Issue.

Dr. Laurent Picot
Dr. Raimundo Gonçalves de Oliveira Junior
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cancer
  • carotenoids
  • heterocycles
  • immunomodulation
  • neurodegenerative diseases
  • phlorotannins
  • phototherapy
  • phycobiliproteins
  • porphyrins
  • signaling pathways

Published Papers (1 paper)

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13 pages, 1787 KiB  
Optimizing Phycocyanin Extraction from Cyanobacterial Biomass: A Comparative Study of Freeze–Thaw Cycling with Various Solvents
by Konstantinos Pispas, Georgios Manthos, Eirini Sventzouri, Maria Geroulia, Savvas Giannis Mastropetros, Sameh Samir Ali and Michael Kornaros
Mar. Drugs 2024, 22(6), 246; - 28 May 2024
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Cyanobacterial phycocyanin pigment is widely utilized for its properties in various industries, including food, cosmetics, and pharmaceuticals. Despite its potential, challenges exist, such as extraction methods impacting yield, stability, and purity. This study investigates the impact of the number of freeze–thaw (FT) cycles [...] Read more.
Cyanobacterial phycocyanin pigment is widely utilized for its properties in various industries, including food, cosmetics, and pharmaceuticals. Despite its potential, challenges exist, such as extraction methods impacting yield, stability, and purity. This study investigates the impact of the number of freeze–thaw (FT) cycles on the extraction of phycocyanin from the wet biomass of four cyanobacteria species (Arthrospira platensis, Chlorogloeopsis fritschii, Phormidium sp., and Synechocystis sp.), along with the impact of five extraction solutions (Tris-HCl buffer, phosphate buffer, CaCl2, deionized water, and tap water) at various pH values. Synechocystis sp. exhibited the highest phycocyanin content among the studied species. For A. platensis, Tris-HCl buffer yielded maximum phycocyanin concentration from the first FT cycle, while phosphate buffer provided satisfactory results from the second cycle. Similarly, Tris-HCl buffer showed promising results for C. fritschii (68.5% of the maximum from the first cycle), with the highest concentration (~12% w/w) achieved during the seventh cycle, using phosphate buffer. Phormidium sp. yielded the maximum pigment concentration from the first cycle using tap water. Among species-specific optimal extraction solutions, Tris-HCl buffer demonstrated sufficient extraction efficacy for all species, from the first cycle. This study represents an initial step toward establishing a universal extraction method for phycocyanin from diverse cyanobacteria species. Full article
(This article belongs to the Special Issue Recent Advances in Marine-Derived Pigments)
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