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Advances in Neuromuscular Care and Treatments
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Advances in Neuromuscular Care and Treatments

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 3800

Special Issue Editors

Dr. Franz Lassner

E-Mail Website
Guest Editor
Medizinische Fakultät, RWTH Aachen University, Aachen, Germany
Interests: brachial plexus surgery; peripheral nerve surgery; reconstructive microsurgery; hand surgery
Dr. Arne Hendrik Böcker

E-Mail Website
Guest Editor
Klinikum Ludwigshafen, Ludwigshafen, Germany
Interests: brachial plexus surgery; peripheral nerve surgery; reconstructive microsurgery; hand surgery

Special Issue Information

Dear Colleagues,

Lesions of the peripheral nerves, causing sensory and motor deficits as well as chronic pain syndromes, are an important issue in medicine today.

This has evolved as a topic of interdisciplinary interest, including faculties such as plastic surgery, trauma surgery, orthopedic surgery, neurosurgery, neurology, neuroradiography, neurosonography and physio-/ergotherapy. Successful motor and sensory reconstruction can be achieved according to the principles of tension-free nerve suture introduced by Millesi and refined by his successors. In situations in which a complete sensory or motor lesion of one extremity is established, we can offer a variety of treatment options, ranging from neurolysis, nerve suture, nerve grafting or nerve transfers, tendon transfers as well as free functional muscle transfers, with or without nerve transfers.   

The aim of this Special Issue is to invite original articles, notable clinical findings, and review articles to discuss the latest advancements of research and clinical experience with respect to the reconstruction of peripheral nerve lesions. A variety of questions come to mind, only to name a small selection: which diagnostic/imaging tools are valid? What can be achieved with interfascicular neurolysis? Can axons travel for distances longer than 30 cm and promote meaningful function? What is the relevance of contralateral nerve transfers? Where is the time limit for nerve reconstruction of high lesions and when should we opt for nerve/muscle transfers? Are artificial nerve guides a realistic alternative when compared to conventional nerve grafts? With this Special Issue, we invite specialists of all faculties to contribute to this exciting field of research.

Dr. Franz Lassner
Dr. Arne Hendrik Böcker
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Published Papers (3 papers)

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Research

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12 pages, 737 KiB  
Article
Gait Pattern in Charcot-Marie-Tooth Disease Type 1A According to Disease Severity
by Jihyun Park, So Young Joo, Byung-Ok Choi, Dae-Hyun Kim, Jong Bum Park, Jong Weon Lee and Deog Young Kim
J. Pers. Med. 2023, 13(10), 1473; https://doi.org/10.3390/jpm13101473 - 08 Oct 2023
Viewed by 1088
Abstract
The aim of this study was to evaluate the characteristics of gait patterns in Charcot-Marie-Tooth disease type 1A (CMT1A) patients according to disease severity. Twenty-two CMT1A patients were enrolled and classified into two groups, according to the disease severity. The healthy control group [...] Read more.
The aim of this study was to evaluate the characteristics of gait patterns in Charcot-Marie-Tooth disease type 1A (CMT1A) patients according to disease severity. Twenty-two CMT1A patients were enrolled and classified into two groups, according to the disease severity. The healthy control group consisted of 22 subjects with no gait impairment. Full barefoot three-dimensional gait analysis with temporospatial, kinematic, and kinetic data was performed among the mild and moderate CMT1A group and the control group. Minimal hip abduction, maximal hip extension generation, peak knee flexion moment at stance, ankle dorsiflexion at initial contact, maximal ankle plantarflexion at push-off and maximal ankle rotation moment at stance in the CMT1A group showed a significant difference compared to the control group (p < 0.05). In the moderate group, there were greater maximal hip flexion angles in swing, and smaller dorsiflexion angles at initial contact compared to the control group and mild group. CMT patients had typical gait characteristics and their gait patterns were different according to severity. The analysis of gait patterns in patients with CMT1A will help to understand gait function and provide important information for the treatment of patients with CMT in the future. Full article
(This article belongs to the Special Issue Advances in Neuromuscular Care and Treatments)
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12 pages, 268 KiB  
Article
Evaluation of the Quality of Life of Patients with Myasthenia Gravis in Greece
by Afrodite Aggelina, Eleftheria Karampli, Georgios Mavrovounis, Ioannis Boutsikos, Ioannis Pantazopoulos, Sotirios Kakavas, Elpida Pavi and Kostas Athanasakis
J. Pers. Med. 2023, 13(7), 1130; https://doi.org/10.3390/jpm13071130 - 12 Jul 2023
Viewed by 839
Abstract
Myasthenia Gravis (MG) patients often report an affected quality of life (QoL). The aim of the current study was to evaluate the QoL of patients with MG in Greece using a specific tool. A cross-sectional online survey was performed. Adult patients were invited [...] Read more.
Myasthenia Gravis (MG) patients often report an affected quality of life (QoL). The aim of the current study was to evaluate the QoL of patients with MG in Greece using a specific tool. A cross-sectional online survey was performed. Adult patients were invited to participate. A questionnaire incorporating the MG-QOL15r scale was distributed, following its translation and cultural adaptation into Greek. Overall, 99 valid responses were submitted. The median age (interquartile range) of the participants was 48.50 (13.50) years and 76.80% were females. One third of the patients mentioned that they could not work/changed jobs after their diagnosis (28.30%) and that they face severe restriction of their everyday activities (26.30%). The mean MG-QOL15r score was 13.50 ± 7.70. Patients with important restriction of everyday activities (p < 0.01), patients with more pronounced need of emotional support (p < 0.01), patients with generalized MG (p < 0.01) and patients with myasthenic crises (p < 0.01) reported lower QoL. This study is the first to report on the affected QoL of the Greek population with MG using the MG-QoL15r scale. Further work should be done to incorporate the routine evaluation of QoL in the care of patients with MG. Full article
(This article belongs to the Special Issue Advances in Neuromuscular Care and Treatments)

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18 pages, 1657 KiB  
Systematic Review
Shielding the Nerve: A Systematic Review of Nerve Wrapping to Prevent Adhesions in the Rat Sciatic Nerve Model
by Maximilian Mayrhofer-Schmid, Tess T. Klemm, Martin Aman, Ulrich Kneser, Kyle R. Eberlin, Leila Harhaus and Arne H. Boecker
J. Pers. Med. 2023, 13(10), 1431; https://doi.org/10.3390/jpm13101431 - 24 Sep 2023
Cited by 2 | Viewed by 1450
Abstract
Background: Peripheral nerve pathology is frequently encountered in clinical practice among peripheral nerve and extremity surgeons. One major factor limiting nerve regeneration and possibly leading to revision surgeries is the development of traumatic or postoperative adhesions and scarring around nerves. In experimental models, [...] Read more.
Background: Peripheral nerve pathology is frequently encountered in clinical practice among peripheral nerve and extremity surgeons. One major factor limiting nerve regeneration and possibly leading to revision surgeries is the development of traumatic or postoperative adhesions and scarring around nerves. In experimental models, different materials have been studied to limit scar tissue formation when wrapped around nerves. Methods: A systematic review of studies describing nerve-wrapping materials in a non-transectional rat sciatic nerve model was performed following the PRISMA guidelines. Literature describing nerve-wrapping methods for the prevention of peripheral nerve scarring in rat sciatic nerve models was identified using PubMed and Web of Science, scanned for relevance and analyzed. Results: A total of 15 original articles describing 23 different materials or material combinations for nerve wrapping were included. The heterogeneity of the methods used did not allow a meta-analysis, thus, a systematic review was performed. Out of 28 intervention groups, 21 demonstrated a preventive effect on scar tissue formation in at least one qualitative or quantitative assessment method. Conclusions: The analyzed literature describes a variety of materials from different origins to limit peripheral nerve scarring and adhesions. Thus, a scar-preventive effect by wrapping peripheral nerves as adhesion prophylaxis seems likely. However, a quantitative comparison of the studies to identify the optimal material or technique is not possible with the diversity of used models and study designs. Therefore, further research needs to be performed to identify the optimal nerve wraps to be used routinely in clinical practice. Full article
(This article belongs to the Special Issue Advances in Neuromuscular Care and Treatments)
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