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Personalized Medicine in Maternal–Fetal Care: From Cervical Insufficiency to Preterm...
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Personalized Medicine in Maternal–Fetal Care: From Cervical Insufficiency to Preterm Birth and Beyond

A Special Issue of Journal of Personalized Medicine (ISSN 2075-4426) belonging to the section "Personalized Medical Care".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 1717

Editor

Dr. Moon-Il Park

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Dongtan Jeil Women’s Hospital, Hwaseong-si 18450, Republic of Korea
Interests: obstetrics; maternal–fetal medicine; high risk pregnancies; cervical insufficiency; preterm birth; double-level cerclage; emergent cerclage; second cerclage

Special Issue Information

Dear Colleagues,

Cervical insufficiency and preterm birth remain leading causes of perinatal morbidity and mortality worldwide. Despite decades of research, individual risk prediction and intervention timing are still challenging.

The concept of mechanical support through cerclage has evolved since the 1950s—from the classic McDonald and Shirodkar techniques to modern double-level and emergent procedures—reflecting our growing understanding of the cervix as a dynamic biological structure.

Recent advances in quantitative elastography, cervical tissue molecular profiling, and AI-based prediction platforms are redefining our ability to model cervical remodeling and preterm birth risk at an individualized level. Integration of multimodal biomarkers—including mechanical, biochemical, and computational parameters—offers unprecedented opportunities for precision diagnostics and preventive interventions in maternal–fetal medicine.

This Special Issue aims to highlight advances in personalized approaches to maternal–fetal care, integrating mechanical, biochemical, and digital parameters for early diagnosis and tailored therapy.

We invite original research articles, reviews, and other types focusing on risk modeling, infection control, cerclage innovation, and multidisciplinary approaches that advance personalized maternal–fetal medicine.

Dr. Moon-Il Park
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cervical insufficiency
  • preterm birth
  • personalized medicine
  • emergent cerclage
  • infection-controlled cerclage
  • maternal–fetal medicine
  • AI-based prediction platforms

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Published Papers (1 paper)

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8 pages, 444 KB  
Perspective
Cervical Insufficiency Beyond Terminology: From Fixed Labels to Pregnancy-Specific Vulnerability in Personalized Maternal–Fetal Care
by Moon-Il Park and Yong-Jin Park
J. Pers. Med. 2026, 16(3), 149; https://doi.org/10.3390/jpm16030149 - 4 Mar 2026
Cited by 1 | Viewed by 1242
Abstract
Over the past two decades, the term cervical incompetence has largely been replaced by cervical insufficiency in clinical guidelines, reflecting efforts to avoid pejorative language and to acknowledge functional variability. However, despite this terminological evolution, the underlying conceptual framework has remained largely static, [...] Read more.
Over the past two decades, the term cervical incompetence has largely been replaced by cervical insufficiency in clinical guidelines, reflecting efforts to avoid pejorative language and to acknowledge functional variability. However, despite this terminological evolution, the underlying conceptual framework has remained largely static, continuing to treat cervical insufficiency as a fixed anatomic defect inferred from obstetric history or single-point measurements. This Perspective argues that such a model inadequately explains the substantial clinical heterogeneity observed across and within pregnancies, limiting its usefulness for individualized clinical interpretation and study design. Drawing on contemporary guideline frameworks, systematic reviews, and international disease classification systems, this article highlights the limitations of static, anatomy-centered approaches and proposes an alternative conceptualization of cervical insufficiency as a dynamic, pregnancy-specific vulnerability. Within this framework, cervical behavior is understood as time-dependent and context-sensitive, shaped by the interplay of mechanical load, biological processes, and gestational timing rather than predetermined structural failure. This conceptualization is intended to inform interpretation across diverse clinical contexts, rather than to redefine diagnostic criteria or existing guideline recommendations. By shifting emphasis from fixed diagnostic labels to trajectories of cervical vulnerability, this Perspective situates cervical insufficiency within the broader continuum of spontaneous preterm birth and aligns its interpretation with the principles of personalized medicine. This conceptual reframing positions cervical insufficiency as a model condition for personalized maternal–fetal care, emphasizing time- and context-aware risk assessment and trajectory-informed clinical decision-making, while providing a coherent foundation for individualized surveillance and future research aimed at improving maternal–fetal outcomes. Full article
(This article belongs to the Special Issue Personalized Medicine in Maternal–Fetal Care: From Cervical Insufficiency to Preterm Birth and Beyond)
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