Biology of Saccharomyces cerevisiae and Mechanisms of Interaction with the Host

A special issue of Journal of Fungi (ISSN 2309-608X).

Deadline for manuscript submissions: closed (28 February 2026) | Viewed by 1632

Special Issue Editors


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Guest Editor
Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, 41125 Modena, Italy
Interests: pathogenesis of opportunistic infections by Candida albicans and other fungi of the genus Candida; fungal biofilm; innate immunity to fungal infections
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, 41125 Modena, Italy
Interests: innate immunity to fungal infections; Candida; mucosal candidiasis; microbiota and mycobiota; fungal and bacterial biofilm; antifungal strategies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Saccharomyces cerevisiae is a yeast “domesticated” by humans which has been used since 10,000 BC to produce fermented beverages and to make bread rise. Today, S. cerevisiae is employed as a “cell factory” not only for food processing, but also as a probiotic in the pharmaceutical industry, and, lately, in the production of biofuels. The presence of S. cerevisiae in human-related environments and its close association with human activities allowed this yeast to adapt to several body sites, where it normally dwells (the skin, mucosal membranes, breast milk, and respiratory and intestinal tracts). Notwithstanding, increasing evidence on the beneficial probiotic role of S. cerevisiae, through its interaction with the human host and with the resident microbiota, shows that it is necessary to acquire more data on its underlying mechanisms.

For this reason, the Journal of Fungi has decided to launch a Special Issue on “Biology of Saccharomyces cerevisiae and Mechanisms of Interaction with the Host”, in order to gather more information on the biological aspects of this yeast linked to its interaction with the human host. Therefore, original research articles and review manuscripts aimed at better understanding the biology of S. cerevisiae are welcome for submission.

Dr. Andrea Ardizzoni
Dr. Eva Pericolini
Guest Editors

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Keywords

  • Saccharomyces cerevisiae
  • microbiota
  • probiotics
  • postbiotics
  • yeasts
  • fungal-host interactions

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Published Papers (1 paper)

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Research

15 pages, 1686 KB  
Article
Untargeted Metabolomic Analysis of Cell-Free Supernatants (CFSs) from Different Clinical Isolates of Saccharomyces cerevisiae and Their Effects on Candida albicans Virulence
by Luca Spaggiari, Gabriele Tedeschi, Giulia Benatti, Michael De Benedittis, Maria Teresa Franzè, Diego Pinetti, Eva Pericolini and Andrea Ardizzoni
J. Fungi 2026, 12(2), 81; https://doi.org/10.3390/jof12020081 - 23 Jan 2026
Viewed by 848
Abstract
Saccharomyces cerevisiae probiotic properties are effective for the treatment of infections by the opportunistic pathogen Candida albicans. Here, we assessed the anti-Candida effect of cell-free supernatants (CFSs) from three different fecal isolates and one ATCC strain of S. cerevisiae. We [...] Read more.
Saccharomyces cerevisiae probiotic properties are effective for the treatment of infections by the opportunistic pathogen Candida albicans. Here, we assessed the anti-Candida effect of cell-free supernatants (CFSs) from three different fecal isolates and one ATCC strain of S. cerevisiae. We evaluated C. albicans growth inhibition through CFUs, and the impairment of virulence factors (adhesion, biofilm formation, and metabolic activity) by crystal violet and XTT assays. An untargeted metabolomic analysis of the CFSs was also performed. The CFSs moderately reduced C. albicans growth, but they could impair C. albicans virulence by reducing its capacity to adhere and to form a biofilm, and by decreasing the metabolic activity of biofilm-embedded fungal cells. The untargeted metabolomic analysis indicated an overexpression of N-acetyl-DL-tryptophan and other molecules derived from its metabolism (kynurenic acid and indole-3-acrylic acid), the dipeptides glycyl-L-leucine, prolyl-leucine, and γ-L-glutamyl-L-leucine, and the unconventional nucleotide inosine in the CFSs from fecal isolates, as compared to the reference strain. Further studies are warranted to better characterize the metabolome of these CFSs. Should the effects described here also be confirmed in vivo, the possible future employment of S. cerevisiae CFSs as a postbiotic aid to the current antifungal therapy may be considered. Full article
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