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Chronic Pulmonary Aspergillosis 2.0
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Chronic Pulmonary Aspergillosis 2.0

A special issue of Journal of Fungi (ISSN 2309-608X).

Deadline for manuscript submissions: closed (15 June 2023) | Viewed by 4542

Special Issue Editor

Dr. Chris Kosmidis

E-Mail Website
Guest Editor
Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
Interests: chronic pulmonary aspergillosis; clinical trials; antifungal agents; pathogenesis; immunotherapy; invasive aspergillosis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic pulmonary aspergillosis (CPA) is an increasingly recognised entity in patients without the classical risk factors for invasive fungal disease. It mainly complicates previously treated tuberculosis (TB) and COPD. Due to the numbers of people with these conditions, the global burden of CPA is significant, particularly in low-resource settings. Despite the obvious global health implications, surprisingly little is known about the pathogenesis, diagnosis, and management of the disease. Some evidence of the presence of subtle immune defects or a genetic susceptibility to CPA has emerged. Diagnosis relies on a combination of radiological and microbiological features and clinician expertise; better validation of diagnostic tests is required. Finally, treating this disease is extremely challenging because long-term treatment is needed and there is only one class of oral agents (i.e., the azoles), and resistance develops promptly, especially in patients with extensive disease and aspergillomas. An individualised, host-targeted approach is most beneficial.

I am pleased to invite you to submit a manuscript to a Special Issue of Journal of Fungi dedicated to CPA. We welcome reviews and original research on host pathogenesis, mycological aspects, diagnostic challenges, and management issues in high- and low-resource settings.

Dr. Chris Kosmidis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic pulmonary aspergillosis
  • Aspergillus
  • diagnosis
  • pathogenesis
  • treatment

Related Special Issue

Published Papers (2 papers)

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Research

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10 pages, 3586 KiB  
Article
Importance of Aspergillus-Specific Antibody Screening for Diagnosis of Chronic Pulmonary Aspergillosis after Tuberculosis Treatment: A Prospective Follow-Up Study in Ghana
by Bright K. Ocansey, Benjamin Otoo, Hafisatu Gbadamosi, Jane S. Afriyie-Mensah, Japheth A. Opintan, Chris Kosmidis and David W. Denning
J. Fungi 2023, 9(1), 26; https://doi.org/10.3390/jof9010026 - 23 Dec 2022
Cited by 2 | Viewed by 1763
Abstract
Chronic pulmonary aspergillosis (CPA) often occurs in patients that have been previously treated for pulmonary tuberculosis (PTB). A limited number of studies have looked at the development of CPA at different times following the completion of a PTB treatment course. This prospective longitudinal [...] Read more.
Chronic pulmonary aspergillosis (CPA) often occurs in patients that have been previously treated for pulmonary tuberculosis (PTB). A limited number of studies have looked at the development of CPA at different times following the completion of a PTB treatment course. This prospective longitudinal study aimed to determine the incidence of CPA at two timepoints, at the end of the PTB treatment (T1) and six months post-treatment (T2). Patients with confirmed PTB from a previous study who were placed on anti-TB medication were followed up and screened for CPA at T1 and T2 by assessing their symptoms, evaluating their quality of life, and screening them for Aspergillus infection by performing antibody testing and cultures. CPA was defined by the Global Action for Fungal Infections (GAFFI) diagnostic algorithm. Forty-one patients were enrolled, of whom thirty-three patients (80%) and twenty-eight patients (68%) were resurveyed at T1 and T2, respectively. The rate of new CPA was 3.3% (1/33) and 7.4% (2/27) at T1 and T2, respectively, with an overall incidence of 10.7% (3/28) among the patients at both T1 and T2. A positive Aspergillus-specific antibody test was an indicator for CPA in all three patients. Aspergillus-specific antibody screening during and after the end of an anti-TB treatment regimen may be important for early detection of CPA in high-PTB-burden settings. Full article
(This article belongs to the Special Issue Chronic Pulmonary Aspergillosis 2.0)
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Review

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11 pages, 977 KiB  
Review
Diagnosis of Chronic Pulmonary Aspergillosis: Clinical, Radiological or Laboratory?
by Aleksandra Barac, Ankica Vujovic, Ana Drazic, Goran Stevanovic, Bianca Paglietti, Katarina Lukic, Maja Stojanovic and Mihailo Stjepanovic
J. Fungi 2023, 9(11), 1084; https://doi.org/10.3390/jof9111084 - 06 Nov 2023
Viewed by 2007
Abstract
Chronic pulmonary aspergillosis (CPA) is a chronic progressive lung disease associated with a poor prognosis and a 5-year mortality rate of approximately 40–50%. The disease is characterized by slowly progressive destruction of the lung parenchyma, in the form of multiple cavities, nodules, infiltrates [...] Read more.
Chronic pulmonary aspergillosis (CPA) is a chronic progressive lung disease associated with a poor prognosis and a 5-year mortality rate of approximately 40–50%. The disease is characterized by slowly progressive destruction of the lung parenchyma, in the form of multiple cavities, nodules, infiltrates or fibrosis. CPA can be challenging to diagnose due to its non-specific symptoms and similarities with other respiratory conditions combined with the poor awareness of the medical community about the disease. This can result in delayed treatment even for years and worsening of the patient’s condition. Serological tests certainly play a significant role in diagnosing CPA but cannot be interpreted without radiological confirmation of CPA. Although many data are published on this hot topic, there is yet no single definitive test for diagnosing CPA, and a multidisciplinary approach which involves a combination of clinical picture, radiological findings, microbiological results and exclusion of other mimicking diseases, is essential for the accurate diagnosis of CPA. Full article
(This article belongs to the Special Issue Chronic Pulmonary Aspergillosis 2.0)
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