Advances in Onychomycosis Research
A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".
Deadline for manuscript submissions: closed (1 May 2025) | Viewed by 1498
Special Issue Editor
Special Issue Information
Dear Colleagues,
The Special Issue, entitled ‘Onychomycosis’, aims to present the precise definition of onychomycosis and address its management with or without the preferred treatment:
- Diagnostic Improvements: Recent research highlights significant advancements in diagnostic techniques for onychomycosis such as polymerase chain reaction (PCR), especially in cases where traditional methods, such as direct microscopy and culture, are negative while the clinical presentation supports onychomycosis.
- The gold-standard treatment for onychomycosis is systemic treatment. Emerging treatments such as topical therapies (new topical treatments) are being developed to improve drug penetration and efficacy, laser therapy and photodynamic therapy (PDT).
- The definition of treatment success: There must be uniformity in clinical studies regarding the definition of therapeutic success in onychomycosis. Since there is usually more than one affected nail in most cases, a single nail showing complete restoration is sufficient evidence of therapeutic success.
- Antifungal Resistance: The issue of antifungal resistance is becoming more prominent. There are various mechanisms by which fungi develop resistance to commonly used antifungals, and novel antifungal compounds with novel mechanisms of action to overcome resistance.
- Prevention and Recurrence: Relapse, reinfection and the host immune response.
To summarize: this Special Issue primarily addresses the correct laboratory diagnosis alongside a clinical picture consistent with onychomycosis, the consideration of pure or combined disorders, the adaptation of appropriate treatment even in cases of resistance, the interpretation of therapeutic success, and ultimately the prevention of recurrence or reinfection.
Prof. Dr. Avner Shemer
Guest Editor
Manuscript Submission Information
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Keywords
- Onychomycosis
- laboratory diagnosis
- Dermatophytes
- yeasts
- molds
- Terbinafine
- Fluconazole
- Itraconazole
- next-generation azoles
- definition of treatment success
- reinfection
- relapse
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