Special Issue "Azole Resistance in Aspergillus spp."
Deadline for manuscript submissions: 31 March 2023 | Viewed by 1790
2. Biosanitary Foundation for Research in the Principality of Asturias (FINBA), 33011 Oviedo, Spain
Interests: mycological diagnosis; antifungal resistance; antifungal tolerance; clinical implication of antifungal resistance; azole resistance in the environment
Interests: Aspergillus molecular biology; antifungal resistance; antifungal tolerance; Aspergillus stress response
Aspergillus spp. fungi affect millions of patients and cause hundreds of thousands of life-threatening infections every year. Azoles have been used for many years as the main antifungal agent to treat and prevent Aspergillus spp. infections. However, these organisms can develop azole resistance in certain environments when exposed to azole compounds used as fungicides or during the long-term treatment of patients with chronic infections. Azole resistance can be devastating as almost 90% of invasive aspergillosis patients infected with a drug-resistant strain die, while chronic patients with resistant infections are administered treatments that are either poorly tolerated or less efficacious. Furthermore, some isolates show the remarkable ability to tolerate azole concentrations greater than the minimal inhibitory concentration, which may also impact clinical outcomes and act as a precursor of azole resistance. Thus, azole resistance poses a significant threat to human health with important economic implications.
This Special Issue is dedicated to Aspergillus spp. azole resistance. Among other topics, it will cover the important research and innovation needed to implement risk reduction strategies that can minimize the emergence of resistance and improve disease management.
Dr. Teresa Peláez
Dr. Clara Valero
Manuscript Submission Information
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- azole resistance molecular mechanisms
- clinical azole resistance
- environmental azole resistance
- evolution of azole resistance
- detection of azole resistance
- azole tolerance/persistence