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Diversity and Secondary Metabolites of Marine Fungi
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Diversity and Secondary Metabolites of Marine Fungi

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Cell Biology, Metabolism and Physiology".

Deadline for manuscript submissions: closed (15 November 2023) | Viewed by 4692

Special Issue Editors

Dr. Fei Cao

E-Mail Website
Guest Editor
College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
Interests: marine fungus; marine nature product; marine drug
Dr. Wei Li

E-Mail Website
Guest Editor
College of Science, Shantou University, Shantou 515063, China
Interests: marine microbiology; fungal diversity; ecological adaptation and function; molecular ecology using omics-based approaches

Special Issue Information

Dear Colleagues,

Increasing evidence from both culture- and omics-based studies has indicated that fungal communities are diverse and abundant in marine ecosystems, with contributions to the nutrient cycling of organic matters. On the other hand, marine fungi have already been revealed to hold much promise in industrial and pharmaceutical applications due to their expression of specific biosynthetic pathways to cope with numerous environmental stresses in the ocean. Over the past few decades, extensive enzymes, novel metabolic properties, and secondary metabolites have been discovered from obligate and marine-derived fungi isolated from a variety of marine substrates including waters, sediments, plants, and animals related to the habitats ranging from coastal to oceanic and shallow water to the deep sea. These findings confirm the attraction and potential of marine fungi in biotechnological applications compared to their terrestrial counterparts.

This Special Issue in the Journal of Fungi invites articles on both fungal diversity and bioactive secondary metabolites of marine fungi with a focus on the diversity and function of marine fungi and marine natural product discovery from fungi. We particularly welcome articles (reviews or original articles) that combine diversity, distribution, classification, ecology, and taxonomy of marine fungi, and biological activities of the new secondary metabolites from marine fungi.

Dr. Fei Cao
Dr. Wei Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine fungus
  • fungal diversity
  • marine natural product
  • ecological adaptation and function
  • bioactivity
  • secondary metabolite
  • molecular ecology using omics-based approach

Published Papers (3 papers)

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Research

10 pages, 1721 KiB  
Communication
Secondary Metabolites with Herbicidal and Antifungal Activities from Marine-Derived Fungus Alternaria iridiaustralis
by Jinqing Fan, Fangfang Guo, Chen Zhao, Hong Li, Tianli Qu, Lin Xiao and Fengyu Du
J. Fungi 2023, 9(7), 716; https://doi.org/10.3390/jof9070716 - 29 Jun 2023
Viewed by 1005
Abstract
Weed and soil-borne pathogens could synergistically affect vegetable growth and result in serious losses. Investigation of agricultural bioactive metabolites from marine-derived fungus Alternaria iridiaustralis yielded polyketides (1–4), benzopyrones (5–7), meroterpenoid derivatives (8), and [...] Read more.
Weed and soil-borne pathogens could synergistically affect vegetable growth and result in serious losses. Investigation of agricultural bioactive metabolites from marine-derived fungus Alternaria iridiaustralis yielded polyketides (1–4), benzopyrones (5–7), meroterpenoid derivatives (8), and alkaloid (9). The structures and absolute configurations of new 1, 3, 5–6, and 8 were elucidated by extensive spectroscopic analyses, as well as comparisons between measured and calculated ECD and 13C NMR data. Compounds 1–4, 6, and 9 showed herbicidal potentials against the radicle growth of Echinochloa crusgalli seedlings. Especially 9 exhibited inhibition rates over 90% at concentrations of 20 and 40 μg/mL, even better than the commonly used chemical herbicide acetochlor. Furthermore, 9 also performed a wide herbicidal spectrum against the malignant weeds Digitaria sanguinalis, Portulaca oleracea, and Descurainia sophia. Compounds 5–8 showed antifungal activities against carbendazim-resistant strains of Botrytis cinerea, with minimum inhibitory concentration (MIC) values ranging from 32 to 128 μg/mL, which were better than those of carbendazim (MIC = 256 μg/mL). Especially 6 exhibited integrated effects against both soil-borne pathogens and weed. Overall, marine-derived fungus A. iridiaustralis, which produces herbicidal and antifungal metabolites 1–9, showed the potential for use as a microbial pesticide to control both weed and soil-borne pathogens. Full article
(This article belongs to the Special Issue Diversity and Secondary Metabolites of Marine Fungi)
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11 pages, 1119 KiB  
Article
Bioactive Alpha-Pyrone and Phenolic Glucosides from the Marine-Derived Metarhizium sp. P2100
by Zhong-Lian Ma, Zhi-Pu Yu, Yao-Yao Zheng, Na Han, Ya-Hui Zhang, Shu-Yue Song, Jun-Qiu Mao, Jiao-Jiao Li, Guang-Shan Yao and Chang-Yun Wang
J. Fungi 2023, 9(1), 28; https://doi.org/10.3390/jof9010028 - 23 Dec 2022
Cited by 5 | Viewed by 1253
Abstract
Glycoside compounds have attracted great interest due to their remarkable and multifarious bioactivities. In this study, four hitherto unknown 4-methoxy-β-D-glucosyl derivatives were obtained and identified from the marine-derived fungus Metarhizium sp. P2100, including three alpha-pyrone glycosides (1–3) [...] Read more.
Glycoside compounds have attracted great interest due to their remarkable and multifarious bioactivities. In this study, four hitherto unknown 4-methoxy-β-D-glucosyl derivatives were obtained and identified from the marine-derived fungus Metarhizium sp. P2100, including three alpha-pyrone glycosides (1–3) and one phenolic glycoside (4). Their planar structures were elucidated by comprehensive spectroscopic analysis, including 1D/2D NMR and HRESIMS. The absolute configurations of 1–3 were determined by a single-crystal X-ray crystallographic experiment, a comparison of the experimental, and a calculated electronic circular dichroism (ECD) spectra, respectively. Compounds 2 and 3 are a pair of rare epimeric pyranoside glycosides at C-7 with a core of aglycone as 2H-pyrone. Compounds 1–4 exhibited weak anti-inflammatory activities. In particular, compounds 1–3 displayed inhibitory activities against α-amylase, showing a potential for the development of a new α-amylase inhibitor for controlling diabetes. Full article
(This article belongs to the Special Issue Diversity and Secondary Metabolites of Marine Fungi)
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11 pages, 1635 KiB  
Article
Bioactive Alkaloids from the Marine-Derived Fungus Metarhizium sp. P2100
by Guang-Shan Yao, Zhong-Lian Ma, Yao-Yao Zheng, Ling Lv, Jun-Qiu Mao and Chang-Yun Wang
J. Fungi 2022, 8(11), 1218; https://doi.org/10.3390/jof8111218 - 17 Nov 2022
Cited by 7 | Viewed by 1766
Abstract
The Metarhizium fungal species are considered the prolific producers of bioactive secondary metabolites with a variety of chemical structures. In this study, the biosynthetic potential of marine-derived fungus Metarhizium sp. P2100 to produce bioactive alkaloids was explored by using the one strain many [...] Read more.
The Metarhizium fungal species are considered the prolific producers of bioactive secondary metabolites with a variety of chemical structures. In this study, the biosynthetic potential of marine-derived fungus Metarhizium sp. P2100 to produce bioactive alkaloids was explored by using the one strain many compounds (OSMAC) strategy. From the rice solid medium (mixed with glucose peptone and yeast broth (GPY)), wheat solid medium (mixed with Czapek) and GPY liquid medium, one rare N-butenone spiroquinazoline alkaloid, N-butenonelapatin A (1), together with nine known compounds (2–10), were isolated and identified. Their structures were elucidated by analysis of the comprehensive spectroscopic data, including 1D and 2D NMR and HRESIMS, and the absolute configuration of 1 was determined by a single-crystal X-ray crystallographic experiment. N-butenonelapatin A (1) represents the first example of N-butenone spiroquinazoline with a rare α, β-unsaturated ketone side chain in the family of spiroquinazoline alkaloids. Compound 4 displayed antibacterial activity against Vibrio vulnificus MCCC E1758 with a minimum inhibitory concentration (MIC) value of 6.25 µg/mL. Compound 7 exhibited antibacterial activities against three aquatic pathogenic bacteria, including V. vulnificus MCCC E1758, V. rotiferianus MCCC E385 and V. campbellii MCCC E333 with the MIC values of 12.5, 12.5 and 6.25 μg/mL, respectively. Compounds 3 and 6 demonstrated anti-inflammatory activity against NO production induced by lipopolysaccharide (LPS) with the IC50 values of 37.08 and 37.48 μM, respectively. In addition, compound 1 showed weak inhibitory activity against the proliferation of tumor cell lines A-375 and HCT 116. These findings further demonstrated that fungi of the Metarhizium species harbor great potentials in the synthesis of a variety of bioactive alkaloids. Full article
(This article belongs to the Special Issue Diversity and Secondary Metabolites of Marine Fungi)
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