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Candida and Candidiasis: From Basics to Clinics
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Candida and Candidiasis: From Basics to Clinics

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Pathogenesis and Disease Control".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1007

Special Issue Editors

Prof. Dr. Arnaldo Lopes Colombo

E-Mail Website
Guest Editor
Special Laboratory of Mycology, Universidade Federal de São Paulo, São Paulo 04023-062, SP, Brazil
Interests: epidemiology of invasive candidiasis and aspergillosis; epidemiology and molecular mechanisms of antifungal resistance; emerging fungal pathogens; new strategies for the diagnosis of fungal infections; new strategies for treating fungal infections
Special Issues, Collections and Topics in MDPI journals
Dr. Marcello Mihailenko Chaves Magri

E-Mail Website
Guest Editor
Infectious Diseases Department, Hospital das Clínicas, University of São Paulo, São Paulo 05403-900, Brazil
Interests: candidemia; epidemiology; mortality; guidelines

Special Issue Information

Dear Colleagues,

Candida is a yeast pathogen able to cause superficial and invasive infections in susceptible populations. It is the most common cause of hospital-acquired fungal infections worldwide and the largest genus of medically important yeasts.

As the prevalence of Candida infections continues to rise, particularly among critically ill patients and immunocompromised individuals, understanding the complex interplay between this fungus and its hosts is more critical than ever.

This Special Issue is dedicated to bridging the gap between fundamental research and clinical practice, focusing on the multifaceted aspects of Candida and candidiasis.

We aim to foster a deeper understanding of Candida species, the biology of candidiasis, and the development of effective diagnostic, treatment, and prevention strategies.

This Special Issue will cover a broad range of topics, including but not limited to the following:

  • The taxonomy, genetics, and molecular biology of Candida species.
  • Pathogenesis and host–pathogen interactions in candidiasis.
  • Epidemiology and risk factors associated with candidiasis in various patient populations.
  • Antifungal resistance in Candida species.
  • Emerging Candida species causing invasive infections.
  • New advances in the diagnosis of candidemia and invasive candidiasis.
  • Challenges in the clinical management of candidemia, intra-abdominal candidiasis, and deep-seated Candida infections.
  • Protocols for antifungal prophylaxis, empirical therapy, and the treatment of proven infections.
  • Immune responses to Candida infections and the development of vaccines.
  • New antifungals with activity against Candida species.
  • Combination antifungal therapy.

We invite contributions from researchers working in the field of medical mycology, microbiology, immunology, infectious diseases, hematology, intensive care medicine, and related disciplines. We welcome original research articles, reviews, case reports complemented by literature reviews, etc.

Prof. Dr. Arnaldo Lopes Colombo
Dr. Marcello Mihailenko Chaves Magri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Candida and candidiasis 
  • taxonomy, genetics, and molecular biology 
  • pathogenesis 
  • host-pathogen interactions 
  • epidemiology 
  • antifungal resistance 
  • emerging Candida species 
  • diagnosis and treatment 
  • protocols 
  • immune responses 
  • antifungal therapy

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

12 pages, 559 KiB  
Article
Candidemia in ICU Patients: What Are the Real Game-Changers for Survival?
by Bianca Leal de Almeida, Caroline Agnelli, Thaís Guimarães, Teresa Sukiennik, Paulo Roberto Passos Lima, Mauro José Costa Salles, Giovanni Luís Breda, Flavio Queiroz-Telles, Ana Verena Almeida Mendes, Luís Fernando Aranha Camargo, Hugo Manuel Paz Morales, Viviane Maria de Carvalho Hessel Dias, Afonso Rafael da Silva Junior, João Nóbrega de Almeida Junior, Camila de Melo Picone, Evangelina da Motta Pacheco Alves de Araújo, Edson Abdala, Flávia Rossi, Arnaldo Lopes Colombo and Marcello Mihailenko Chaves Magri
J. Fungi 2025, 11(2), 152; https://doi.org/10.3390/jof11020152 - 17 Feb 2025
Viewed by 792
Abstract
Candidemia infection remains a critical challenge in intensive care units (ICUs), with high morbidity and mortality rates despite advances in therapeutic practices. This multicenter prospective surveillance study assessed the epidemiology, clinical management, and mortality predictors of candidemia in critically ill patients across two [...] Read more.
Candidemia infection remains a critical challenge in intensive care units (ICUs), with high morbidity and mortality rates despite advances in therapeutic practices. This multicenter prospective surveillance study assessed the epidemiology, clinical management, and mortality predictors of candidemia in critically ill patients across two periods (2010–2012 and 2017–2018) in 11 tertiary hospitals in Brazil. Among 314 ICU patients with candidemia, the overall mortality rate was 60.2%, with no significant reduction over time (58.8% vs. 62.6%, p = 0.721). Candida albicans was the predominant pathogen (43.6%), followed by C. tropicalis (20%) and C. glabrata (13.7%). The use of echinocandins increased significantly in the second period (21.1% to 41.7%, p < 0.001); however, 70% of patients still did not receive these agents as first-line therapy. Catheter removal due to candidemia was performed in only 52.1% of cases but was associated with improved 30-day survival (p < 0.001). Multivariate analysis identified cancer, inadequate treatment, and vasoactive drug use as independent predictors of mortality. Our findings underscore persistent gaps in adherence to guidelines, particularly regarding timely echinocandin initiation and catheter removal. Strengthening therapeutic strategies focused on these key interventions is essential to improving outcomes for ICU patients with candidemia. Full article
(This article belongs to the Special Issue Candida and Candidiasis: From Basics to Clinics)
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