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Functional Biomaterial for Bone Regeneration (2nd Edition)
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Functional Biomaterial for Bone Regeneration (2nd Edition)

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 2391

Special Issue Editors

Dr. Marija Čandrlić

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Guest Editor
Department of Integrative Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, 31000 Osijek, Croatia
Interests: biology and application of biomaterials used in regenerative dental medicine; guided tissue regeneration; histology; immunohistochemistry; dental implantology; oral surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Željka Perić Kačarević

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Guest Editor
Department of Anatomy, Histology, Embryology, Pathological Anatomy and Pathological Histology, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia
Interests: biomaterials; histology; bone tissue regeneration; regenerative medicine; macrophages; collagen; resorbable metal
Special Issues, Collections and Topics in MDPI journals
Dr. Matej Tomas

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Guest Editor
Department of Dental Medicine, Faculty of Dental Medicine and Health Osijek, J.J. Strossmayer University of Osijek, Crkvena 21, 31 000 Osijek, Croatia
Interests: biomaterials; histology; bone tissue regeneration; immunohistochemistry; histomorphometry; periodontology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is generally recognized that the success of bone regeneration depends not only on the choice of a particular surgical technique and the clinical experience of the therapist, but also on the knowledge, correct selection, and use of various biomaterials. Therefore, the science of biomaterials is one of the fastest growing disciplines in dentistry, and a deeper understanding of the properties of existing biomaterials, as well as the development of new ones, requires special research attention.

Building upon the success of the first edition, which focused broadly on the use of biomaterials in bone regeneration, this second edition will place a stronger emphasis on the biological mechanisms underlying material performance. This Special Issue will highlight how advanced functional biomaterials, such as bioactive scaffolds, resorbable and non-resorbable membranes for guided bone regeneration, growth-factor–incorporated matrices, and hybrid materials modulate cellular behavior, angiogenesis, soft and hard tissue formation.

In addition, contributions addressing histological and immunohistochemical analyses, innovative processing methods (e.g., additive manufacturing, surface modifications), and biological interactions (e.g., host–material integration, immune modulation, molecular mechanisms) are also welcome. By integrating basic science, translational, preclinical, and clinical perspectives, the second edition aims to provide a more comprehensive understanding of the interactions between biomaterials and host tissues.

This Special Issue will be of great interest to professionals in regenerative dentistry, oral and maxillofacial surgery, implantology, and tissue engineering seeking to advance the science and clinical application of next-generation biomaterials.

Dr. Marija Čandrlić
Dr. Željka Perić Kačarević
Dr. Matej Tomas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional biomaterials
  • bone regeneration
  • guided bone regeneration (GBR)
  • membranes (resorbable and non-resorbable)
  • biological mechanisms
  • histological and immunohistochemical analysis

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Related Special Issue

Published Papers (2 papers)

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Research

16 pages, 3701 KB  
Article
Early Osseointegration in a Sheep Tibia Model: Correlating Digital Periapical Radiograph Gray-Level and RGB-Derived Metrics with Histologic Tissue Composition
by Sergio Alexandre Gehrke, Jaime Aramburú Júnior, Tiago Luis Eilers Treichel, Germán Odella Colla, Gustavo Coura, Bruno Freitas Mello, Márcio de Carvalho Formiga, Fátima de Campos Buzzi, Sergio Rexhep Tari and Antonio Scarano
J. Funct. Biomater. 2025, 16(11), 415; https://doi.org/10.3390/jfb16110415 - 7 Nov 2025
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Abstract
Objective: This study aimed to evaluate peri-implant tissue changes during early osseointegration using a combined approach of digital radiographic analysis, RGB pseudocolorization, and histomorphometry in a sheep tibia model. Materials and Methods: Thirty titanium implants were placed in the tibiae of six adult [...] Read more.
Objective: This study aimed to evaluate peri-implant tissue changes during early osseointegration using a combined approach of digital radiographic analysis, RGB pseudocolorization, and histomorphometry in a sheep tibia model. Materials and Methods: Thirty titanium implants were placed in the tibiae of six adult sheep and evaluated at 14 and 28 days post-implantation. Digital periapical radiographs were acquired, grayscale values and RGB channel intensities were measured using Fiji/ImageJ, and compared with histological parameters (bone tissue, collagen, and medullary spaces) quantified from picrosirius–hematoxylin-stained sections. Manual overlay of radiographic and histological images was performed to ensure spatial correspondence of regions of interest. Statistical analyses assessed differences over time and correlations between image data and histological composition. Results: Radiographic grayscale values and histologically measured bone and collagen increased significantly from 14 to 28 days (p < 0.01), while medullary spaces decreased (p < 0.001), indicating progressive bone formation and matrix maturation. RGB analysis revealed significant increases in green channel intensity and decreases in red channel intensity (p < 0.05), while the blue channel remained stable. At 14 days, strong correlations were observed between blue channel intensity and bone tissue (r = 0.81; p = 0.015), and between green channel intensity and collagen (r = 0.98; p < 0.001). Visual overlays demonstrated alignment between radiographic high-density zones and histologically dense bone regions. Conclusions: RGB pseudocolorized radiographic analysis, correlated with histological findings, offers a non-invasive and reproducible method for early detection of peri-implant tissue maturation. This feasibility correlation study provides a foundation for future investigations integrating imaging, histology, and biomechanical testing. Full article
(This article belongs to the Special Issue Functional Biomaterial for Bone Regeneration (2nd Edition))
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18 pages, 3059 KB  
Article
Clinical and Radiological Evaluation of Flap and Flapless Procedures with Biomaterials in Alveolar Ridge Preservation
by Ewa Dolińska, Ewa Duraj, Marcin Bernaczyk, Magdalena Sulewska and Małgorzata Pietruska
J. Funct. Biomater. 2025, 16(9), 345; https://doi.org/10.3390/jfb16090345 - 14 Sep 2025
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Abstract
Although ridge preservation procedures have been shown to prevent post-extraction bone loss, the effectiveness of using a flap or flapless surgical approach remains unclear. The aim of the study was to compare the mentioned above alveolar ridge preservation procedures in the esthetic region [...] Read more.
Although ridge preservation procedures have been shown to prevent post-extraction bone loss, the effectiveness of using a flap or flapless surgical approach remains unclear. The aim of the study was to compare the mentioned above alveolar ridge preservation procedures in the esthetic region of maxilla. Twenty-nine patients were randomly assigned to receive flap (n = 14) or flapless (n = 15) alveolar ridge preservation procedure. Sockets were grafted with alloplastic biomaterial, then covered with a collagen membrane in both groups. Clinical examinations were performed over a 6-month observation period and radiological (CBCT) examination was conducted before and 6 months after treatment. For both after flap and flapless procedures, there was a reduction in interdental papillae height and keratinized tissue width, increase in buccal soft tissues thickness with a decrease in radiological buccal bone plate width, decrease in radiological buccal and lingual plate height (significantly for the flapless group) and radiological alveolar process width reduction (significantly in flapless group at the height of 5 mm and 7 mm from the bottom of the socket). A decrease in the radiological buccal bone plate width was observed, where the further measuring point was from the bottom of the alveolus. In the mucoperiosteal flap preparation, group buccal bone plate width reduction at the height 3 mm, 5 mm and 7 mm was significant and in the flapless group a significant decrease was observed from 5 to 9 mm from the bottom of the socket. Despite ridge preservation, there is soft tissue thickening and a decrease in bone height and width regardless of the flap/flapless method used. Full article
(This article belongs to the Special Issue Functional Biomaterial for Bone Regeneration (2nd Edition))
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