Special Issue "2021 Feature Papers by JDB’s Editorial Board Members"

A special issue of Journal of Developmental Biology (ISSN 2221-3759).

Deadline for manuscript submissions: 15 November 2021.

Special Issue Editor

Prof. Dr. Simon J. Conway
E-Mail Website
Guest Editor
Herman B Wells Center for Pediatric Research, 1044 West Walnut Street, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Interests: birth defects; developmental basis of congenital and acquired cardiopulmonary diseases; neonatal lung alveolar septation; transgenic mouse modelling; cell lineage tracing; neural crest; fibroblast-to-myofibroblast transition; extracellular matrix
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Special Issue Information

Dear Colleagues,

This Special Issue on “2021 Feature Papers by JDB’s Editorial Board Members” represents a collection of papers submitted exclusively by its Editorial Board Members (EBMs), as well as invited papers from relevant experts. By representing different areas of research on developmental biology conducted in the laboratories, this Special Issue shall introduce JDB as a first-class platform for reporting scientific data.

Authors can submit their manuscripts online at www.mdpi.com by registering and logging in the following website: https://susy.mdpi.com/user/login. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the Special Issue website.

Prof. Simon J. Conway
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Developmental Biology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

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Article
Zebrafish Optomotor Response and Morphology Are Altered by Transient, Developmental Exposure to Bisphenol-A
J. Dev. Biol. 2021, 9(2), 14; https://doi.org/10.3390/jdb9020014 - 02 Apr 2021
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Abstract
Estrogen-specific endocrine disrupting compounds (EDCs) are potent modulators of neural and visual development and common environmental contaminants. Using zebrafish, we examined the long-term impact of abnormal estrogenic signaling by testing the effects of acute, early exposure to bisphenol-A (BPA), a weak estrogen agonist, [...] Read more.
Estrogen-specific endocrine disrupting compounds (EDCs) are potent modulators of neural and visual development and common environmental contaminants. Using zebrafish, we examined the long-term impact of abnormal estrogenic signaling by testing the effects of acute, early exposure to bisphenol-A (BPA), a weak estrogen agonist, on later visually guided behaviors. Zebrafish aged 24 h postfertilization (hpf), 72 hpf, and 7 days postfertilization (dpf) were exposed to 0.001 μM or 0.1 μM BPA for 24 h, and then allowed to recover for 1 or 2 weeks. Morphology and optomotor responses (OMRs) were assessed after 1 and 2 weeks of recovery for 24 hpf and 72 hpf exposure groups; 7 dpf exposure groups were additionally assessed immediately after exposure. Increased notochord length was seen in 0.001 μM exposed larvae and decreased in 0.1 μM exposed larvae across all age groups. Positive OMR was significantly increased at 1 and 2 weeks post-exposure in larvae exposed to 0.1 μM BPA when they were 72 hpf or 7 dpf, while positive OMR was increased after 2 weeks of recovery in larvae exposed to 0.001 μM BPA at 72 hpf. A time-delayed increase in eye diameter occurred in both BPA treatment groups at 72 hpf exposure; while a transient increase occurred in 7 dpf larvae exposed to 0.1 μM BPA. Overall, short-term developmental exposure to environmentally relevant BPA levels caused concentration- and age-dependent effects on zebrafish visual anatomy and function. Full article
(This article belongs to the Special Issue 2021 Feature Papers by JDB’s Editorial Board Members)
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Review

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Review
Biological and Clinical Significance of Mosaicism in Human Preimplantation Embryos
J. Dev. Biol. 2021, 9(2), 18; https://doi.org/10.3390/jdb9020018 - 07 May 2021
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Abstract
Applications and indications of assisted reproduction technology are expanding, but every new approach is under scrutiny and thorough consideration. Recently, groups of assisted reproduction experts have presented data that support the clinical use of mosaic preimplantation embryos at the blastocyst stage, previously excluded [...] Read more.
Applications and indications of assisted reproduction technology are expanding, but every new approach is under scrutiny and thorough consideration. Recently, groups of assisted reproduction experts have presented data that support the clinical use of mosaic preimplantation embryos at the blastocyst stage, previously excluded from transfer. In the light of published contemporary studies, with or without clinical outcomes, there is growing evidence that mosaic embryos have the capacity for further in utero development and live birth. Our in-depth discussion will enable readers to better comprehend current developments. This expansion into the spectrum of ART practices requires further evidence and further theoretical documentation, basic research, and ethical support. Therefore, if strict criteria for selecting competent mosaic preimplantation embryos for further transfer, implantation, fetal growth, and healthy birth are applied, fewer embryos will be excluded, and more live births will be achieved. Our review aims to discuss the recent literature on the transfer of mosaic preimplantation embryos. It also highlights controversies as far as the clinical utilization of preimplantation embryos concerns. Finally, it provides the appropriate background to elucidate and highlight cellular and genetic aspects of this novel direction. Full article
(This article belongs to the Special Issue 2021 Feature Papers by JDB’s Editorial Board Members)

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: A Zebrafish Model of Lysosomal Myopathy Highlights Roles for Proteostasis in Extracellular Matrix Regulation
Authors: Clarissa Henry; et al.
Affiliation: University of Maine, Orono, ME 04469, USA

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