Feature Papers in Journal of Developmental Biology 2025

A special issue of Journal of Developmental Biology (ISSN 2221-3759).

Deadline for manuscript submissions: 30 September 2025 | Viewed by 537

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Special Issue Information

Dear Colleagues,

Developmental biology remains one of the most dynamic fields in life sciences, offering critical insights into how organisms grow, differentiate, and maintain their form. From the molecular to the organismal level, the processes governing cellular organization and development are central to understanding both normal physiology and disease. Recent advancements have expanded our ability to explore these complex developmental systems, revealing novel mechanisms and refining our knowledge of known pathways.

The Journal of Developmental Biology is excited to announce the upcoming Special Issue “Feature Papers in Journal of Developmental Biology 2025”. This Special Issue will spotlight groundbreaking research and comprehensive reviews on the development of multicellular organisms, encompassing all levels from molecules to entire organisms.

We welcome submissions that span the breadth of developmental biology, focusing on either fundamental mechanisms or their applications in health and disease. Topics of interest include but are not limited to the following:

  • Mechanisms and genetics of development;
  • Cell differentiation and specialization;
  • Embryonic development and growth;
  • Tissue and organ development;
  • Metamorphosis and regenerative processes;
  • Genetics of rare developmental disorders;
  • RNA and transcriptomics in developmental biology;
  • The evolution of developmental processes;
  • Development of the nervous system;
  • Integration of developmental biology with other disciplines such as molecular biology, genetics, and neurobiology.

We invite researchers in developmental biology, genetics, molecular biology, and related fields to contribute their most significant work. Original research articles, reviews, and perspectives that provide new insights into developmental biology and its applications are highly encouraged.

By gathering a diverse collection of studies, this Special Issue aims to highlight the current frontiers in developmental biology, offering a platform for researchers to share their discoveries and inspire future investigations.

We look forward to receiving your valuable contributions!

Prof. Dr. Simon J. Conway
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Developmental Biology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • developmental biology
  • cellular organization
  • molecular mechanisms
  • cell differentiation
  • embryonic development
  • tissue development
  • organ development
  • regenerative processes
  • metamorphosis
  • developmental genetics
  • rare developmental disorders
  • RNA biology
  • transcriptomics
  • evolution of development
  • nervous system development
  • developmental pathways
  • molecular biology
  • neurobiology
  • genetic regulation
  • disease models in development

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Published Papers (1 paper)

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16 pages, 9375 KiB  
Article
The Loss of Tafazzin Transacetylase Activity Is Sufficient to Drive Testicular Infertility
by Paige L. Snider, Elizabeth A. Sierra Potchanant, Catalina Matias, Donna M. Edwards, Jeffrey J. Brault and Simon J. Conway
J. Dev. Biol. 2024, 12(4), 32; https://doi.org/10.3390/jdb12040032 - 26 Nov 2024
Viewed by 377
Abstract
Barth syndrome (BTHS) is a rare, infantile-onset, X-linked mitochondriopathy exhibiting a variable presentation of failure to thrive, growth insufficiency, skeletal myopathy, neutropenia, and heart anomalies due to mitochondrial dysfunction secondary to inherited TAFAZZIN transacetylase mutations. Although not reported in BTHS patients, male infertility [...] Read more.
Barth syndrome (BTHS) is a rare, infantile-onset, X-linked mitochondriopathy exhibiting a variable presentation of failure to thrive, growth insufficiency, skeletal myopathy, neutropenia, and heart anomalies due to mitochondrial dysfunction secondary to inherited TAFAZZIN transacetylase mutations. Although not reported in BTHS patients, male infertility is observed in several Tafazzin (Taz) mouse alleles and in a Drosophila mutant. Herein, we examined the male infertility phenotype in a BTHS-patient-derived D75H point-mutant knockin mouse (TazPM) allele that expresses a mutant protein lacking transacetylase activity. Neonatal and adult TazPM testes were hypoplastic, and their epididymis lacked sperm. Histology and biomarker analysis revealed TazPM spermatogenesis is arrested prior to sexual maturation due to an inability to undergo meiosis and the generation of haploid spermatids. Moreover, TazPM testicular mitochondria were found to be structurally abnormal, and there was an elevation of p53-dependent apoptosis within TazPM seminiferous tubules. Immunoblot analysis revealed that TazPM gamete genome integrity was compromised, and both histone γ-H2Ax and Nucleoside diphosphate kinase-5 protein expression were absent in juvenile TazPM testes when compared to controls. We demonstrate that Taz-mediated transacetylase activity is required within mitochondria for normal spermatogenesis, and its absence results in meiotic arrest. We hypothesize that elevated TazPM spermatogonial apoptosis causes azoospermia and complete infertility. Full article
(This article belongs to the Special Issue Feature Papers in Journal of Developmental Biology 2025)
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