Dear Colleagues,

The demand for non-invasive and safe technology for aesthetic treatments of the skin paved the way for the research of new technologies working with more efficacy and less collateral effects. Plasma skin regeneration is a relatively recent technique that uses ionizing energy produced by a plasma radiofrequency (PRF) device.

Plasma is also defined “the fourth state of the matter” derived by ionization of neutral gases present in the air. If a sufficient energy is applied by a radiofrequency generator to the gases, electrons escape from their atoms inducing a positive charge and ionization. This effect increases the number of electrons, creating positive charged particles called ions, and the dissociation of molecular bonds. Plasma energy deriving from the ionization of atmospheric gas between the tip of the device and the skin, induces a vaporization of the superficial layers and instantly heats in a controlled and uniform manner. Plasma sublimation works leaving a layer of intact and desiccated epidermis that acts as a natural biologic dressing and promotes a more rapid recovery, avoiding damaging the deeper layers of the skin and predisposing to a better healing. High precision, short operation time, no bleeding, less damage to other tissues, rapid formation of postoperative protection layer, fast healing of wound surface, immediate return to normal activity, no visible scars, no hyperpigmentation, no infection, no pain, and very slight inflammatory reaction after sessions, are the biggest advantages of the technique.

Applications are many, ranging from the removal of unsightly skin lesions, such as fibromas, dermal nevi, xanthelasma palpebrarum, dyskeratosis, angiomas, warts, solar lentigo and seborrheic keratosis, to the correction of scars, treatment of blepharochalasis (non-surgical blepharoplasty), periocular and perioral wrinkles, and active acne. In conclusion, PRF ablation can actually be considered a well‐tolerated, painless, safe, effective, and low‐cost procedure for skin treatments.

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• biomedical plasma applications
• long-wave plasma radiofrequency ablation
• plasma energy treatments
• plasma medicine
• benign skin lesions treatment
• aesthetic medicine
• facial skin aesthetic treatments
• nonsurgical radiofrequency treatment