Pulmonary Arterial Hypertension: The Unmet Needs in the Diagnosis and Therapeutic Management
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pulmonology".
Deadline for manuscript submissions: closed (30 October 2024) | Viewed by 217
Special Issue Editors
Interests: vascular diseases; pulmonary arterial hypertension
Special Issue Information
Dear Colleagues,
PAH is a life-threatening syndrome characterized by the remodeling of the distal pulmonary arteries, leading to increased pulmonary vascular resistance, right heart failure and premature death. In the past three decades, there have been significant advancements, leading to novel therapeutic strategies and a better understanding of the pathogenesis of PAH.
Nevertheless, PAH remains an incurable disease. To facilitate decision making on treatment strategy, European PH guidelines have proposed a periodic dynamic risk stratification that plays a key role in choosing the most appropriate treatment strategy, aiming at slowing disease progression. However, the current risk stratification tools may not sufficiently capture the heterogeneity of the disease. Indeed, approximately 60% of patients end up in the intermediate risk class, with an unsatisfactory clinical status, high mortality rate and clinical worsening, thereby highlighting the limited discrimination capacity of current scores. Experts agree that considering additional variables involved in the pathophysiology of PAH could pave the way for personalized treatment, leading to an improved prognosis.
We are pleased to invite you to contribute to this Special Issue with the following aims:
- Define new prognostic markers to improve the risk stratification of PAH patients.
- Guide PAH specialists in the definition of the optimal timing for parenteral prostanoids and/or for lung transplantation.
- Focus on new therapeutic strategies acting on new genetic pathways.
- Review the available implantable devices for the hemodynamic monitoring of PAH patients affected by right heart failure.
Suggested themes and article types for submissions: we will include original articles, perspective papers and reviews.
Dr. Silvia Papa
Dr. Giovanna Manzi
Guest Editors
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Keywords
- vascular diseases
- pulmonary arterial hypertension
- right failure
- afterload mismatch
- function capacity and exercise test
- imaging
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