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Kidney Transplantation: Challenges, Advances and Lessons Learnt
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Kidney Transplantation: Challenges, Advances and Lessons Learnt

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 25 January 2026 | Viewed by 1098

Special Issue Editors

Dr. Karim Soliman

E-Mail Website
Guest Editor
1. Transplant Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
2. Transplant Surgery, Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
3. Medical Services, Ralph H. Johnson VA Medical Center, Charleston, SC 29401, USA
Interests: transplant; living donation; rejection; dialysis
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Tibor Fülöp

E-Mail Website
Guest Editor
1. Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
2. Medical Services, Ralph H. Johnson VA Medical Center, Charleston, SC 29401, USA
Interests: dialysis; CRRT; electrolytes; transplant
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Kidney transplantation remains a crucial and expanding topic in nephrology and transplant medicine, with major advances and ongoing challenges. This Special Issue, "Kidney Transplantation: Challenges, Advances and Lessons Learnt", aims to investigate major discoveries, ongoing challenges, and the wealth of knowledge gained through decades of clinical practice and research. This Special Issue seeks to provide a complete review of the present state of kidney transplantation by focusing on a variety of themes such as patient selection criteria, immunosuppressive treatments, long-term graft survival, and the complexities of multi-organ transplant consideration. We hope to inform and encourage continuing progress toward better patient outcomes and transplant success by highlighting cutting-edge research, expert opinions, and practical experience lessons.

Dr. Karim Soliman
Prof. Dr. Tibor Fülöp
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • kidney transplantation
  • nephrology
  • transplant medicine
  • patient selection criteria
  • immunosuppressive treatment
  • long-term outcomes
  • graft survival
  • complication
  • multi-organ transplant consideration
  • innovation

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Published Papers (2 papers)

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Research

15 pages, 2761 KB  
Article
Soluble Thrombomodulin as a Marker of Endothelial Injury in Early Post-Transplant Period: A Comparative Study of Simple Hypothermia and Pulsatile Machine Perfusion in Kidney Graft Preservation
by Maciej Kotowski, Anna Prekwa, Adam Nowacki, Iga Stukan, Karol Tejchman, Jerzy Sieńko, Przemysław Nowacki, Bogusław Machaliński and Marek Ostrowski
J. Clin. Med. 2026, 15(1), 269; https://doi.org/10.3390/jcm15010269 - 29 Dec 2025
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Abstract
Background: Ischemia–reperfusion injury is a major contributor to early graft dysfunction after kidney transplantation and is associated with endothelial damage, reflected by circulating soluble thrombomodulin (sTM). This exploratory study aimed to assess very early graft-level changes in renal vein sTM during reperfusion [...] Read more.
Background: Ischemia–reperfusion injury is a major contributor to early graft dysfunction after kidney transplantation and is associated with endothelial damage, reflected by circulating soluble thrombomodulin (sTM). This exploratory study aimed to assess very early graft-level changes in renal vein sTM during reperfusion using a paired-kidney design, in which kidneys from the same donor were preserved using different strategies: static cold storage (SCS) and hypothermic machine perfusion (HMP). Methods: Renal vein blood samples were collected intraoperatively at 1 and 30 min after reperfusion. Plasma sTM concentrations were determined using ELISA. Early graft function was monitored during the first 7 days post-transplantation. Results: Cold ischemia time was longer in the HMP group than in the SCS group (20 ± 8 h vs. 13 ± 6 h, p < 0.05). At 1 min post-reperfusion, sTM levels were comparable between groups. In the HMP group, sTM decreased significantly between 1 and 30 min after reperfusion, whereas no change was observed in the SCS group. Between-group differences at either time point did not reach statistical significance. Early renal function parameters improved in both groups, with no significant inter-group differences. No cases of delayed graft function or graft thrombosis occurred. Conclusions: Kidney preservation strategy may modulate very early graft-level endothelial responses during reperfusion, reflected by renal vein sTM dynamics. Although a limited sample size may have reduced the ability to detect between-group differences, very early renal vein sTM measurements may provide insight into ischemia–reperfusion injury. Clinical relevance requires validation in larger studies. Full article
(This article belongs to the Special Issue Kidney Transplantation: Challenges, Advances and Lessons Learnt)
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10 pages, 539 KB  
Article
Determinants of Return to Work in Kidney Transplant Recipients—A Study from the West Pomeranian Region of Poland
by Maria Piątak, Sylwia Wieder-Huszla, Joanna Owsianowska, Anna Jurczak, Tomasz Śluzar and Marek Myślak
J. Clin. Med. 2025, 14(23), 8549; https://doi.org/10.3390/jcm14238549 - 2 Dec 2025
Viewed by 409
Abstract
Background: Kidney transplantation enables not only longer survival but also reintegration into professional and social life. Understanding the determinants of post-transplant employment is crucial for optimizing rehabilitation programs. Methods: A cross-sectional study was conducted between 2019 and 2021 among 94 kidney transplant recipients [...] Read more.
Background: Kidney transplantation enables not only longer survival but also reintegration into professional and social life. Understanding the determinants of post-transplant employment is crucial for optimizing rehabilitation programs. Methods: A cross-sectional study was conducted between 2019 and 2021 among 94 kidney transplant recipients treated in two outpatient clinics. Data were collected using a structured interview and medical record analysis. Sociodemographic and clinical variables were assessed. Statistical analysis included chi-square tests, Spearman’s correlation, and logistic regression. All variables that demonstrated statistical significance in the univariate analysis were entered into the multivariate logistic regression model to identify independent predictors of post-transplant employment. A p-value < 0.05 was considered significant. Results: Prior to transplantation, 67.0% of patients were professionally inactive. After transplantation, 66.0% resumed employment, with 41.9% returning to work within six months. Return to work was positively correlated with higher education (p < 0.009), good financial status (p < 0.040), and longer time since transplantation (p < 0.001). Employment prior to transplantation, donor type, and duration of dialysis also significantly influenced outcomes. In the multivariate logistic regression, only marital status and place of residence remained independent predictors of return to work. Conclusions: More than half of transplant recipients successfully returned to work. Sociodemographic (education, marital status, financial situation, residence) and medical factors (dialysis duration, donor type, time since transplantation, prior employment) determined vocational reintegration. Further multicenter, longitudinal studies are needed to identify modifiable factors and design interventions enhancing post-transplant employability. Full article
(This article belongs to the Special Issue Kidney Transplantation: Challenges, Advances and Lessons Learnt)
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