Bees: Physiology, Immunity and Developmental Biology

A special issue of Insects (ISSN 2075-4450). This special issue belongs to the section "Social Insects and Apiculture".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 1278

Special Issue Editors


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Guest Editor
1. Department of Entomology, National Chung Hsing University, Taichung, Taiwan
2. Doctoral Program in Microbial Genomics, National Chung Hsing University and Academia Sinica, Taichung, Taiwan
Interests: bee biology; microbiology; insect biochemistry and physiology

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Guest Editor
1. Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
2. Research Center of Deep Technology in Beekeeping and Bee Products for Sustainable Development Goals (SMART BEE SDGs), Chiang Mai University, Chiang Mai 50200, Thailand
3. Center of Excellence in Microbial Diversity and Sustainable Utilization, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
Interests: microbiome; pathogens; bees; microbes

Special Issue Information

Dear Colleagues,

Bees are essential pollinators with complex biological systems. Their physiology includes specialized adaptations for flight, pheromone-based communication, and efficient foraging. Their immune system is innate, using mechanisms like antimicrobial peptides and phagocytosis to fight pathogens. Developmental biology in honey bees is regulated by diet—especially royal jelly—and hormones such as juvenile hormone and ecdysone, which determine caste differentiation and guide metamorphosis.

However, global bee populations are in decline due to multiple stressors. Key factors include pathogen infections (e.g., Varroa destructor mites, viruses), pesticide exposure (particularly neonicotinoids), habitat loss, climate change, and nutritional stress from monoculture agriculture. These pressures compromise immunity, disrupt development, and reduce colony survival, posing serious threats to both ecosystems and agriculture.

Dr. Ming-Cheng Wu
Dr. Terd Disayathanoowat
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

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Keywords

  • bees
  • physiology
  • immunity
  • development biology
  • bee declining factors

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Published Papers (1 paper)

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Review

25 pages, 399 KB  
Review
An Enquiry into the Status of American Foulbrood Therapeutics
by Olivia Ducommun-Dit-Verron, Gemma Zerna and Travis Beddoe
Insects 2026, 17(3), 312; https://doi.org/10.3390/insects17030312 - 13 Mar 2026
Viewed by 850
Abstract
Managed colonies of the Western honey bee, Apis mellifera, are essential to global food security by ensuring the pollination of a wide array of crops that are crucial for human consumption. However, substantial declines in managed honey bee populations have been reported [...] Read more.
Managed colonies of the Western honey bee, Apis mellifera, are essential to global food security by ensuring the pollination of a wide array of crops that are crucial for human consumption. However, substantial declines in managed honey bee populations have been reported worldwide, including in Australia, the United States and Europe. These losses have been attributed to the multifaceted interplay of stressors encompassing agrochemical impact, climate fluctuations, pathogens, suboptimal forage conditions, and habitat reduction. In particular, Paenibacillus larvae, the causative agent of American foulbrood (AFB), is one of the most destructive bacterial pathogens for honey bees due to its high transmissibility, environmental persistence, and capacity to cause complete colony collapse. Recurrent and widespread AFB outbreaks impose significant economic and biosecurity burdens on apiarists, exacerbating declines in pollination services and agricultural productivity. This review synthesises the current landscape of therapeutic strategies targeting AFB, including bacteriophage-based approaches, vaccine development, probiotics, and essential oils, and evaluate their reported field applications, efficacy, and practical limitations. Bacteriophages and immune-priming approaches show the greatest potential to reduce larval mortality and pathogen load, although their application is constrained by formulation stability, delivery challenges, and limited large-scale field validation. Probiotics and essential oils produce highly variable and inconsistent effectiveness under field conditions. Overall, these alternatives currently represent promising complementary tools rather than standalone treatments, underscoring the need for further investigation. Full article
(This article belongs to the Special Issue Bees: Physiology, Immunity and Developmental Biology)
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