Insect Vector Physiology and Competence: Interactions and Adaptations

A special issue of Insects (ISSN 2075-4450).

Deadline for manuscript submissions: 30 April 2026 | Viewed by 79

Special Issue Editors

College of Agricultural & Environmental Sciences, University of Georgia, Athens, GA 30602, USA
Interests: insect-microbiome ecology and evolution; vector physiology; vector adaptations; symbiosis; insect-pathogenic microbes
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Guest Editor
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
Interests: insect physiology; immunology; circulatory physiology; insect-pathogen interactions

Special Issue Information

Dear Colleagues,

This Special Issue highlights current advances in understanding the physiological, immunological, and ecological interactions that govern vector competence and adaptation, with a focus on arthropod disease vectors such as mosquitoes. As the global burden of vector-borne diseases persists and the effectiveness of traditional control strategies declines due to rising insecticide and drug resistance, there is an urgent need to uncover novel insights into the internal biology of vectors and their interactions with pathogens and symbionts.

We welcome contributions that explore how physiological and immunological traits shape a vector's ability to acquire, maintain, and transmit pathogens. Topics of interest include—but are not limited to—innate immune responses, hemolymph circulation, reproduction, hormones, sensory systems, metabolic regulation, and how these systems are influenced by age, environmental stressors, microbial interactions, and infection history. Studies that span molecular, cellular, and whole-organism levels are especially encouraged, as are those connecting these mechanisms to life history traits and evolutionary adaptation.

By integrating perspectives from insect vector biology, immunology, microbiology, and ecology, this Special Issue aims to broaden our understanding of vector competence and physiology and promote innovative approaches for vector control and disease prevention.

Dr. Yin Wang
Prof. Dr. Julián F. Hillyer
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Insects is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • insect vector physiology
  • vector competence
  • symbiosis
  • vector immunology
  • host–pathogen interactions
  • microbial interactions
  • vector adaptation
  • pesticide resistance

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Published Papers (1 paper)

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Research

23 pages, 4296 KB  
Article
Warmer Temperature Accelerates the Aging-Dependent Decrease in Female Ovary Size, Delays Male Accessory Gland Development, and Accelerates Aging-Dependent Changes in Reproductive Gene Expression in Anopheles gambiae Mosquitoes
by Lindsay E. Martin, Tania Y. Estévez-Lao, Megan I. Grant, Norbu Y. Shastri and Julián F. Hillyer
Insects 2025, 16(9), 921; https://doi.org/10.3390/insects16090921 - 2 Sep 2025
Abstract
In most mosquito species, reproduction requires mating between the female and the male, followed by the female blood-feeding, completing oogenesis, and laying eggs. Warmer environmental temperature and aging both reduce mosquito fecundity and fertility, and warmer temperature accelerates the aging-dependent decline in reproduction [...] Read more.
In most mosquito species, reproduction requires mating between the female and the male, followed by the female blood-feeding, completing oogenesis, and laying eggs. Warmer environmental temperature and aging both reduce mosquito fecundity and fertility, and warmer temperature accelerates the aging-dependent decline in reproduction such that reproductive impairment manifests earlier in life. To shed light on how this warming-based acceleration of reproductive senescence occurs, we investigated how temperature (27 °C, 30 °C, and 32 °C) and aging interactively shape female and male reproductive tissue size in the African malaria mosquito, Anopheles gambiae. In blood-fed females, we discovered that warmer temperature accelerates the aging-dependent decrease in the size of the ovaries but not the spermatheca. In males, we discovered that warmer temperature lessens and delays the aging-dependent increase in the size of the male accessory glands but not the testes. Next, we measured the expression of reproductive genes in females and males. In female reproductive tissues, warmer temperature accelerates the aging-dependent decrease in the expression of vitellogenin and the aging-dependent increase in the expression of MISO and HPX15. In male reproductive tissues, warmer temperature accelerates an aging-dependent decrease in the expression of Plugin, TGase3, phLP, and CYP315A1. Altogether, these data shed light on how physical and transcriptional changes underpin the warming-based acceleration of an aging-dependent decline in mosquito fecundity and fertility. Full article
(This article belongs to the Special Issue Insect Vector Physiology and Competence: Interactions and Adaptations)
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