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State-of-the-Art Molecular Endocrinology and Metabolism in France
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State-of-the-Art Molecular Endocrinology and Metabolism in France

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 2166

Special Issue Editors

Dr. David Coelho

E-Mail Website
Guest Editor
Inserm UMRS 1256 NGERE - Nutrition, Genetics, and Environmental Risk Exposure, University of Lorraine, Nancy, France
Interests: inborn errors of metabolism; monocarbon; vitamin B12; folate
Dr. Didier F. Pisani

E-Mail Website
Guest Editor
Laboratory of Molecular PhysioMedicine (LP2M), Faculty of Medicine, University Côte d'Azur, CNRS, Nice, France
Interests: adipocyte; metabolism; nutrition; obesity; oxidative stress; ischemia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to provide an up-to-date and comprehensive view on the state-of-the-art of endocrinology and metabolism in France.

Based on long-term traditions of fundamental science in France, we would like to provide a comprehensive insight into the state-of-the-art of research activities in the country. All kinds of articles are welcome, including contributions concerning original investigations, as well as reviews in the field. The covered topics of interest include, but are not limited to, the following:

  • Endocrine systems and endocrine-related diseases;
  • Molecular, cellular, genetic, epigenetic, developmental approaches, and animal models;
  • Novel insights into physiology, pathophysiology, and therapeutics;
  • Neuroendocrinology and neuroendocrine control of endocrine axes;
  • Classical glands (thyroid, adrenal, pituitary, parathyroid, testis, ovary, pituitary, etc.) and other endocrine systems: gut, bone, liver, etc.;
  • Lipids and bone metabolism;
  • Hormones, paracrine factors, receptors and binding components, nuclear receptors membrane receptors, and the signal transduction pathway;
  • Steroid biosynthetic enzymes, metabolism of hormones, neurotransmitters, etc.;
  • Cellular interactions and factors involved;
  • Energy expenditure;
  • Diabetes;
  • Infertility and reproductive diseases;
  • Obesity;
  • Osteoporosis;
  • Aging;
  • Endocrine-related tumors and cancer;
  • Endocrine disruption;
  • Cross-disciplinary and integrative studies;
  • Comparative aspects of endocrinology.

Dr. David Coelho
Dr. Didier F. Pisani
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

12 pages, 2432 KiB  
Article
The Role of Apoptosis and Autophagy in the Hypothalamic-Pituitary-Adrenal (HPA) Axis after Traumatic Brain Injury (TBI)
by Serpil Taheri, Züleyha Karaca, Ecmel Mehmetbeyoglu, Zuhal Hamurcu, Zeynep Yilmaz, Fatma Dal, Venhar Çınar, Halil Ulutabanca, Fatih Tanriverdi, Kursad Unluhizarci, Minoo Rassoulzadegan and Fahrettin Kelestimur
Int. J. Mol. Sci. 2022, 23(24), 15699; https://doi.org/10.3390/ijms232415699 - 10 Dec 2022
Cited by 2 | Viewed by 1790
Abstract
Traumatic brain injury (TBI) is a major health problem affecting millions of people worldwide and leading to death or permanent damage. TBI affects the hypothalamic–pituitary–adrenal (HPA) axis either by primary injury to the hypothalamic–hypophyseal region or by secondary vascular damage, brain, and/or pituitary [...] Read more.
Traumatic brain injury (TBI) is a major health problem affecting millions of people worldwide and leading to death or permanent damage. TBI affects the hypothalamic–pituitary–adrenal (HPA) axis either by primary injury to the hypothalamic–hypophyseal region or by secondary vascular damage, brain, and/or pituitary edema, vasospasm, and inflammation. Neuroendocrine dysfunctions after TBI have been clinically described in all hypothalamic–pituitary axes. We established a mild TBI (mTBI) in rats by using the controlled cortical impact (CCI) model. The hypothalamus, pituitary, and adrenals were collected in the acute (24 h) and chronic (30 days) groups after TBI, and we investigated transcripts and protein-related autophagy (Lc3, Bcln1, P150, Ulk, and Atg5) and apoptosis (pro-caspase-3, cleaved caspase-3). Transcripts related to autophagy were reduced in the hypothalamus, pituitary, and adrenals after TBI, however, this was not reflected in autophagy-related protein levels. In contrast, protein markers related to apoptosis increased in the adrenals during the acute phase and in the pituitary during the chronic phase. TBI stresses induce a variation of autophagy-related transcripts without modifying the levels of their proteins in the HPA axis. In contrast, protein markers related to apoptosis are increased in the acute phase in the adrenals, which could lead to impaired communication via the hypothalamus, pituitary, and adrenals. This may then explain the permanent pituitary damage with increased apoptosis and inflammation in the chronic phase. These results contribute to the elucidation of the mechanisms underlying endocrine dysfunctions such as pituitary and adrenal insufficiency that occur after TBI. Although the adrenals are not directly affected by TBI, we suggest that the role of the adrenals along with the hypothalamus and pituitary should not be ignored in the acute phase after TBI. Full article
(This article belongs to the Special Issue State-of-the-Art Molecular Endocrinology and Metabolism in France)
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