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Antitumor Activity of Natural Product

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 559

Special Issue Editor


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Guest Editor
Faculty of Natural Sciences, University of Haifa, Haifa, Israel
Interests: endocrinology and metabolism; integrative and complementary medicine; toxicology; cancer

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to explore the potential of natural products as therapeutic and preventive agents in the context of cancer. Natural compounds derived from plants, marine organisms, mushrooms, and microorganisms have historically served as a rich source of bioactive molecules, many of which have demonstrated anticancer properties, including the ability to induce apoptosis, inhibit angiogenesis, modulate immune responses, and interfere with cancer cell proliferation and metastasis. 

The scope of this Issue encompasses the identification, characterization, and mechanistic evaluation of natural products with proven or potential anticancer activity, as well as their integration into modern oncology—either as standalone therapies or as adjuvants to conventional treatments like chemotherapy and radiation. Related topics include drug discovery and development, molecular pharmacology, chemosensitization, nutraceuticals, and ethnopharmacology, with particular emphasis on compounds such as flavonoids, alkaloids, terpenoids, and polyphenols. 

The publications in this Issue will contribute to the growing body of evidence supporting the role of natural products in the prevention, management, and treatment of various cancers.

Prof. Dr. Fuad Fares
Guest Editor

Manuscript Submission Information

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Keywords

  • natural products
  • cancer treatment
  • cancer prevention
  • medicinal plants
  • medicinal mushrooms

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Published Papers (1 paper)

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Research

17 pages, 2854 KB  
Article
Induction of Extrinsic Apoptotic Pathway in Pancreatic Cancer Cells by Apteranthes europaea Root Extract
by Rinat Bar-Shalom, Lana Abdelhak, Wafa Zennouhi, Farid Khallouki, Laila Benbacer and Fuad Fares
Int. J. Mol. Sci. 2025, 26(20), 10221; https://doi.org/10.3390/ijms262010221 - 21 Oct 2025
Viewed by 427
Abstract
Pancreatic cancer is an extremely deadly disease with few effective treatment options and the lowest survival rate among all types of cancer. As a result, there is an urgent need for the development of new and more effective treatment strategies. Natural products have [...] Read more.
Pancreatic cancer is an extremely deadly disease with few effective treatment options and the lowest survival rate among all types of cancer. As a result, there is an urgent need for the development of new and more effective treatment strategies. Natural products have long been a vital source of drug discovery, offering unique bioactive compounds, and representing a promising source for new, effective, and less toxic treatments. In the present study, we aimed to investigate the effects of Apteranthes europaea (Guss.) Murb (A. europaea) root extract on the growth of pancreatic cancer cells. The proliferation assay (XTT) and real-time analysis using the IncuCyte Live-Cell Analysis System, following treatment of PL45 and Mia PaCa-2 pancreatic cancer cells with escalating concentrations (50–200 µL) to A. europaea root extract, demonstrated the progression of apoptosis. Apoptosis induction was confirmed through cell cycle analysis and Annexin V/PI double staining assays. Western blot analysis revealed the distinct activation of caspase-8, accompanied by the cleavage of caspase-3 and Poly (ADP-ribose) polymerase (PARP). Interestingly, no activation of caspase-9 was observed, suggesting the involvement of the extrinsic apoptotic pathway. Our findings suggest that A. europaea extract may be a potential novel strategy for treating pancreatic cancer. Full article
(This article belongs to the Special Issue Antitumor Activity of Natural Product)
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