Molecular Neuropathology of Alzheimer’s Disease: Tau, Amyloid-β, and Novel Protein Associations
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 22
Special Issue Editors
Interests: Alzheimer’s disease; molecular neuropathology; tau and amyloid beta; neurodegeneration; biomarkers and therapeutics
Interests: molecular neuropathology of Alzheimer’s disease; tau and amyloid beta pathology in postmortem brain tissue; brain donation and autopsy-based research; ethical, cultural, and logistical dimensions of brain donation; inclusion of underrepresented populations in postmortem research; molecular and morphological biomarkers derived from human brain tissue; neuroinflammation and glial pathology in donated brains; translational neuroscience grounded in human tissue studies; artificial intelligence applied to postmortem neuropathological analysis
Special Issue Information
Dear Colleagues,
Alzheimer’s disease (AD) is the most common cause of dementia and represents a global challenge for neuroscience. Its neuropathology is characterized by the accumulation of hyperphosphorylated tau in neurofibrillary tangles and amyloid beta in extracellular plaques, processes that exert synergistic effects on neuronal function. In recent years, new proteins and genetic factors such as APOE, APP, PSEN1, and PSEN2, along with emerging modulators of protein aggregation and neuroinflammation, have been identified, expanding the molecular landscape of AD. These discoveries open opportunities for the development of reliable biomarkers and innovative therapeutic strategies, supported by technologies such as artificial intelligence applied to neuropathological analysis. Research in this area is crucial for advancing a comprehensive understanding of the disease and for designing interventions that can transform the future of neurodegeneration.
We are pleased to invite you to participate in this Special Issue dedicated to Alzheimer’s disease, one of the most dynamic and strategically important areas in contemporary neuroscience research. The aim is to assemble a collection of at least ten articles that address, from multiple perspectives, the complex interactions among tau, amyloid beta, and emerging proteins, thereby broadening the scope of molecular neuropathology.
This Special Issue seeks to become an international reference by integrating original research articles, critical reviews, and conceptual essays that offer new insights into biomarkers, pathogenic mechanisms, and therapeutic strategies. If the target of ten contributions is reached, the Issue will also be published as a printed book, providing a platform with greater visibility and long-term impact for the selected works.
This Special Issue aims to provide an up-to-date overview that integrates morphological, biochemical, and molecular findings, while promoting interdisciplinary dialogue to drive the development of new diagnostic and therapeutic strategies.
Suggested themes and article types for submissions include the following:
- Molecular interactions between tau and amyloid beta: mechanisms of synergy and neuronal toxicity.
- Emerging proteins in Alzheimer’s disease pathogenesis, including TDP-43, alpha-synuclein, fused in sarcoma (FUS), and others.
- Genetics and risk factors: APOE, APP, PSEN1/2, and newly identified loci associated with risk or protective mechanisms.
- Neuroinflammation and glial responses: the role of microglia and astrocytes in disease progression.
- Molecular and morphological biomarkers: advances in early diagnosis and clinical monitoring.
- Artificial intelligence and neuropathological analysis: applications in neuroimaging, digital atlases, and disease progression prediction.
- Innovative therapeutic strategies: immunotherapy, tau and amyloid beta modulators, and combination approaches.
- Experimental models: organoids, animal models, and in vitro approaches for studying Alzheimer’s disease.
- Clinical and translational dimensions: correlations between neuropathological findings and cognitive manifestations.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Original research articles: experimental or clinical studies presenting novel and unpublished findings.
- Critical reviews: syntheses of recent advances and discussions of ongoing controversies in the field.
- Perspectives / conceptual essays: theoretical proposals or reflections on emerging directions in research.
- Case studies: detailed analyses of individual patients or unique neuropathological collections.
- Technical notes: innovations in immunohistochemistry protocols, microscopy, or molecular analysis.
We look forward to receiving your contributions.
Dr. José Luna-Muñoz
Dr. Alejandra Morlett-Paredes
Guest Editors
Manuscript Submission Information
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Keywords
- tauopathies and protein aggregation
- amyloid beta and neurotoxicity
- emerging proteins in neurodegeneration
- molecular and morphological biomarkers
- innovative therapies and experimental targets
- artificial intelligence and neuropathological analysis
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