Special Issue "Advanced Research on Tumor Endothelial Cells"
Deadline for manuscript submissions: closed (31 January 2020).
Interests: tumor angiogenesis; antiangiogenic therapy; tumor microenvironment; tumor endothelial cell
Interests: angiogenesis; vasculogenesis; endothelium; tumor; stem cell; development
Tumor blood vessels supply the tumor with oxygen and nutrients and provide a gateway for tumor metastasis; thus, tumor progression depends on angiogenesis. Since the approval of the first antiangiogenic drug, bevacizumab, tumor endothelial cells (TECs) have been considered “the second most important target for cancer therapy”. Antiangiogenic drugs have shown their benefit when used in combination with chemotherapeutic drugs. However, it has been reported that these drugs have several issues that need to be overcome, such as side effects and drug resistance. Recent studies have elucidated that TECs differ from normal endothelial cells (NECs) both morphologically and physiologically, contrary to previous presumptions. Additionally, it has been reported that TECs are not homogeneous and constitute a heterogeneous population. To develop novel cancer therapy, it is important to study TECs. This Special Issue focuses on tumor endothelial cell biology and discussing the consequence of their altered phenotypes.
Prof. Dr. Kyoko Hida
Prof. Dr. Nobuyuki Takakura
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Tumor angiogenesis
- Antiangiogenic therapy
- Tumor microenvironment
- Tumor endothelial cell