Genetic Susceptibility to Carcinogen-Induced Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: closed (15 May 2014) | Viewed by 29262
Special Issue Editor
Special Issue Information
Dear Colleagues,
Most human cancers are without a clear inheritance pattern and are believed to be multifactorial, resulting from interactions of genetic and environmental factors. These environmental factors include carcinogens such as chemicals, ultraviolet light, and viruses. Epidemiological studies, as well as animal studies, support the hypothesis that interindividual risk of developing cancer as a result of environmental carcinogen exposure is modified by multiple allelic variants of tumor susceptibility genes. Tumor susceptibility alleles have a low penetrance, can act to increase or decrease risk, and act additively to modify risk of cancer development. They are involved in DNA repair, immune response, carcinogen metabolism, cellular proliferation, differentiation, and death, as well as other cancer-related mechanisms. The mapping and isolation of such low penetrance genes in humans is complicated by the multiplicity of unlinked loci involved. This, together with the absence of clear-cut familial inheritance patterns, necessitates development of sophisticated analytical techniques and animal models to detect candidate genes that underlie tumor susceptibility loci. Rodent cancer models have been useful experimental tools for identifying and characterizing tumor susceptibility genes. Importantly, these genes have also been associated with cancer risk in humans, demonstrating the utility of using rodent models to identify genes that modify susceptibility to cancer. Articles in this Special Issue will address research aimed at identifying and characterizing genes that modify tumor susceptibility in rodent cancer models. In addition, this Special Issue will address the mechanisms by which these genes modify the response to carcinogen exposure.
Dr. Joe M. Angel
Guest Editor
Submission
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Keywords
- rodent models
- complex traits
- quantitative trait loci
- tumor susceptibility loci
- genetic risk
- carcinogenesis
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