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Current Research on Lipidomics

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 25 August 2026 | Viewed by 1521

Special Issue Editor


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Guest Editor
Department of Analytical Chemistry, Faculty of Chemistry, Gdańsk Tech, Narutowicza 11/12, 80-233 Gdańsk, Poland
Interests: analytics; chromatography; high resolution mass spectrometry; sample preparation; identification; farmaceutical analysis; metabolomics; lipidomics; water analysis; food analysis
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Special Issue Information

Dear Colleagues,

Lipidomics has become a crucial field for understanding the diverse roles of lipids in health and disease across humans, animals, plants, and food systems. Current research focuses on characterizing lipid species, elucidating their metabolic pathways, and clarifying how lipid alterations influence physiological and pathological processes in organisms ranging from mammals to crops and microorganisms. In nutrition and food science, lipidomics reveals how dietary fats from plant and animal sources affect metabolism and health, while in agriculture it helps explain plant stress responses and crop quality.

Advances in analytical technologies now enable high-resolution lipid profiling in complex biological and food matrices, supporting the discovery of biomarkers for early diagnosis, food quality assessment, and personalized therapies. By providing insights into membrane structure, energy metabolism, and cell signaling, lipidomics plays an important role in nutrition, oncology, neurology, and metabolic disorders, as well as plant and animal sciences.

This Special Issue highlights current approaches in lipidomic analysis across diverse sample types, covering the full workflow—from sample preparation and extraction to advanced analytical systems and data processing. Emphasis is placed on innovative methodologies for qualitative and quantitative lipid analysis that define the current state of the art.

Prof. Dr. Agata Kot-Wasik
Guest Editor

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Keywords

  • lipids 
  • hyphenated chromatography–mass spectrometry 
  • biological samples 
  • sample preparation

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Published Papers (1 paper)

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Review

22 pages, 1104 KB  
Review
Phospholipid Transfer Protein (PLTP) in Cholesterol Handling: Implications for Mitochondrial Lipid Homeostasis in Human iPSC-Derived Cardiomyocytes
by Dhienda C. Shahannaz and Tadahisa Sugiura
Int. J. Mol. Sci. 2026, 27(8), 3617; https://doi.org/10.3390/ijms27083617 - 18 Apr 2026
Viewed by 1272
Abstract
Phospholipid transfer protein (PLTP) is a lipid transfer protein classically studied in the context of plasma lipoprotein metabolism, high-density lipoprotein (HDL) remodeling, and cardiovascular disease risk. PLTP facilitates phospholipid transfer between lipoproteins and regulates HDL particle size and composition through interactions with apolipoprotein [...] Read more.
Phospholipid transfer protein (PLTP) is a lipid transfer protein classically studied in the context of plasma lipoprotein metabolism, high-density lipoprotein (HDL) remodeling, and cardiovascular disease risk. PLTP facilitates phospholipid transfer between lipoproteins and regulates HDL particle size and composition through interactions with apolipoprotein A-I and apolipoprotein A-II. While its systemic roles in cholesterol handling, reverse cholesterol transport, and inflammatory signaling are well established, the cell-autonomous functions of PLTP within cardiomyocytes remain poorly defined, particularly in human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). Extensive experimental and clinical studies demonstrate that PLTP enhances ABCA1-dependent cholesterol efflux primarily by stabilizing ABCA1 at the plasma membrane and by promoting the generation of lipid-poor apolipoprotein A-I and pre-β HDL particles, which serve as efficient cholesterol acceptors; the magnitude of these effects depends on cellular context, PLTP expression levels, and the availability of lipid acceptors. PLTP expression is metabolically regulated and widely distributed across tissues, including macrophages and other non-hepatic cells, supporting roles beyond circulating lipoprotein remodeling. Altered PLTP activity has been linked to atherosclerosis, cardiovascular disease, and inflammatory pathways, underscoring its relevance to cardiac pathophysiology. Emerging evidence further suggests that intracellular cholesterol distribution, rather than total cholesterol content alone, critically influences mitochondrial membrane composition, bioenergetics, and stress signaling in cardiomyocytes. These observations raise the possibility that PLTP-regulated lipid flux may indirectly shape mitochondrial function by modulating cellular cholesterol homeostasis. This review synthesizes current knowledge of PLTP biology, cholesterol metabolism, and lipoprotein remodeling, and integrates these concepts with emerging frameworks in cardiomyocyte lipid metabolism and mitochondrial physiology. We highlight human iPSC-derived cardiomyocytes as a strategic and translationally relevant platform to investigate PLTP’s non-canonical, cell-intrinsic roles, identify critical knowledge gaps, and propose future directions for elucidating how PLTP may influence mitochondrial function in human cardiac cells. Full article
(This article belongs to the Special Issue Current Research on Lipidomics)
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