Insights into the Pathogenesis of Autoimmune Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 25
Special Issue Editor
Interests: autoimmunity; type 1 diabetes; endocrinopathies; T regulatory cells; autoreactive T cells; nanotechnologies; NK cells; extracellular vesicles; immunoregulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The incidence of autoimmune diseases is increasing worldwide. The etiopathogenesis is multifactorial, based on complex interactions among genetic factors, environmental factors that are still unclear, and stochastic events. It is generally recognized that autoimmune diseases stem from a breakdown in immune regulation that leads to the expansion of autoreactive CD4+ and CD8+ T cells, autoantibody-producing B lymphocytes, and the activation of the innate immune system. A deep knowledge of the mechanisms underlying their etiopathogenesis, including the establishment of central tolerance at perinatal age and peripheral tolerance, is fundamental in preventing and treating these conditions. A particular focus for the scientific community is on insulin-dependent diabetes mellitus and other autoimmune endocrine organ and non-organ specific disorders, systemic lupus erythematosus, vasculitides, vitiligo, conditions of the nervous system, and polyautoimmunity.
In this Special Issue, we will discuss recent discoveries on the pathogenesis of autoimmune diseases. This publication will provide a platform for the development of novel immunotherapies.
Dr. Alessandra Fierabracci
Guest Editor
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Keywords
- autoimmune diseases
- immune regulation
- immunotherapies
- systemic lupus erythematosus
- vasculitides
- vitiligo
- polyautoimmunity
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