The Products of Bone Resorption and Their Role in Metabolism

Dear Colleagues,

The aim of this issue is to raise awareness of the role(s) that bone resorption plays in providing products and factors to the body to promote metabolic needs and to create metabolic problems. Thus, calcium, phosphorus, magnesium, and transforming growth factor beta have been recognized as products of bone resorption. In my previous work and that of others, calcium has been recognized as pro-inflammatory, as it can stimulate or inhibit chemokine production and stimulate the NLRP3 inflammasome. Phosphate and magnesium have been associated with providing substrates for ATP formation in skeletal muscle, and TGFbeta has been shown to have paracrine effects on muscle catabolism. It is likely that there are many unrecognized factors liberated during bone resorption, and it is likely, too, that the known factors described above also play other metabolic roles. Any new light that this topic can shed on the products of bone resorption may contribute to our overall understanding of the process and its effects in health and disease. Furthermore, a better understanding of the process may help us to develop new therapeutic modalities for conditions in which bone resorption plays a significant role.

Topics of interest include:

1. An overview of the process of bone resorption as we currently understand it.
2. Specific disease conditions associated with hyperresorption of bone, including: a) Paget's disease, b) primary hyperparathyroidism, c) renal osteodystrophy and secondary hyperparathyroidism, d) osteogenesis imperfecta, e) metastatic bone disease. This should include a description of the effects of these diseases on skeletal and cardiac muscle
3. Factors released from bone during resorption, including: a) calcium, b) phosphorus, c) magnesium, d) transforming growth factor beta, e) undercarboxylated osteocalcin, f) others?
4. inflammation-induced bone resorption
5. Anti-resorptives and the effects of blocking factor release from bone

Prof. Dr. Gordon L. Klein
Guest Editor

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