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The Products of Bone Resorption and Their Role in Metabolism

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 4245

Special Issue Editor


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Guest Editor
Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch at Galveston, Galveston, TX 77555-0165, USA
Interests: bone and muscle interactions; musculoskeletal system contributions to hypermetabolism; metabolic effects of products of bone resorption; clinical trials of anti-resorptives
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Special Issue Information

Dear Colleagues,

The aim of this issue is to raise awareness of the role(s) that bone resorption plays in providing products and factors to the body to promote metabolic needs and to create metabolic problems. Thus, calcium, phosphorus, magnesium, and transforming growth factor beta have been recognized as products of bone resorption. In my previous work and that of others, calcium has been recognized as pro-inflammatory, as it can stimulate or inhibit chemokine production and stimulate the NLRP3 inflammasome. Phosphate and magnesium have been associated with providing substrates for ATP formation in skeletal muscle, and TGFbeta has been shown to have paracrine effects on muscle catabolism. It is likely that there are many unrecognized factors liberated during bone resorption, and it is likely, too, that the known factors described above also play other metabolic roles. Any new light that this topic can shed on the products of bone resorption may contribute to our overall understanding of the process and its effects in health and disease. Furthermore, a better understanding of the process may help us to develop new therapeutic modalities for conditions in which bone resorption plays a significant role.

Topics of interest include:

  1. An overview of the process of bone resorption as we currently understand it.
  2. Specific disease conditions associated with hyperresorption of bone, including: a) Paget's disease, b) primary hyperparathyroidism, c) renal osteodystrophy and secondary hyperparathyroidism, d) osteogenesis imperfecta, e) metastatic bone disease. This should include a description of the effects of these diseases on skeletal and cardiac muscle
  3. Factors released from bone during resorption, including: a) calcium, b) phosphorus, c) magnesium, d) transforming growth factor beta, e) undercarboxylated osteocalcin, f) others?
  4. inflammation-induced bone resorption
  5. Anti-resorptives and the effects of blocking factor release from bone

Prof. Dr. Gordon L. Klein
Guest Editor

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Keywords

  • bone resorption
  • calcium
  • phosphorus
  • magnesium
  • transforming growth factor beta (TGFbeta)
  • undercarboxylated osteocalcin
  • NLRP3 inflammasome
  • inflammation-induced bone resorption
  • anti-resorptives
  • blocking factor

Published Papers (1 paper)

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Review

20 pages, 2226 KiB  
Review
Interplay between Inflammation and Pathological Bone Resorption: Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives
by M Alaa Terkawi, Gen Matsumae, Tomohiro Shimizu, Daisuke Takahashi, Ken Kadoya and Norimasa Iwasaki
Int. J. Mol. Sci. 2022, 23(3), 1786; https://doi.org/10.3390/ijms23031786 - 4 Feb 2022
Cited by 37 | Viewed by 3679
Abstract
Bone is a mineralized and elastic connective tissue that provides fundamental functions in the human body, including mechanical support to the muscles and joints, protection of vital organs and storage of minerals. Bone is a metabolically active organ that undergoes continuous remodeling processes [...] Read more.
Bone is a mineralized and elastic connective tissue that provides fundamental functions in the human body, including mechanical support to the muscles and joints, protection of vital organs and storage of minerals. Bone is a metabolically active organ that undergoes continuous remodeling processes to maintain its architecture, shape, and function throughout life. One of the most important medical discoveries of recent decades has been that the immune system is involved in bone remodeling. Indeed, chronic inflammation has been recognized as the most significant factor influencing bone homeostasis, causing a shift in the bone remodeling process toward pathological bone resorption. Bone osteolytic diseases typified by excessive bone resorption account for one of the greatest causes of disability worldwide, with significant economic and public health burdens. From this perspective, we discuss the recent findings and discoveries highlighting the cellular and molecular mechanisms that regulate this process in the bone microenvironment, in addition to the current therapeutic strategies for the treatment of osteolytic bone diseases. Full article
(This article belongs to the Special Issue The Products of Bone Resorption and Their Role in Metabolism)
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