Recent Progress in the Development of Anticancer Prodrugs
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 3991
Special Issue Editor
Interests: proteases; mass cytometry; cancer prodrugs; activity-based probes; caspases; cell death; unnatural amino acids; enzymes imaging; biological chemistry
Special Issue Information
Dear Colleagues,
Cancer is undoubtedly among the most complex systems in biology, and despite the significant research effort that has been made in several past decades, this disease is still responsible for millions of deaths worldwide. The overall success of cancer treatment is dependent on the combination of early diagnosis, accurate patient stratification and the selection of personalized treatment. Current treatment options for cancer include chemotherapy, surgery, radiation and immunotherapy. Nowadays one of the most promising chemotherapeutic strategy to combat cancer are prodrugs. This system enables the precise delivery of the cargo (drug, toxic payload) to the cancer cells, and the release of free drug upon intra-tumoral internalization or within tumor microenvironment.
This special issue of the International Journal of Molecular Sciences entitled “Recent Progress in the Development of Anticancer Prodrugs” will focus on recent chemical- and biological-based strategies for the development of new treatment options for cancer, including antibody-drug conjugates, peptide-drug conjugates, pro-antibodies, aptamer-drug conjugates, nanomaterials and more. Therefore, the aim of this issue is to present the structural and mechanistic aspects of modern anticancer prodrugs, their biological and clinical efficacy, as well as the ongoing efforts focusing on optimizing prodrug structures in terms of targeted delivery, conjugation chemistry, linkers technology and payloads potency. Contributions on these topics are welcome, including original research and reviews.
Dr. Marcin Poreba
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer therapy
- targeted therapy
- prodrugs
- antibody-drug conjugates
- peptide-drug conjugates
- aptamer-drug conjugates
- pro-antibodies
- enzymes
- proteases
- personalized medicine
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
