Research Advances in Protein Misfolding
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".
Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 1891
Special Issue Editor
Special Issue Information
Dear Colleagues,
Protein-misfolding diseases have been the focus of intense basic and clinical research. We know that protein aggregation in cells is usually tightly controlled, and misfolded proteins are generally removed before accumulation can occur. For reasons not clearly understood, in some individuals, this degradation process breaks down and misfolded proteins aggregate to form amyloids as time progresses. Decades of research has revealed that protein misfolding often activates aggregation and amyloid formation, which template their aberrant structures onto the native protein.
We now know that the largest obstacle to drug development against these unnerving human diseases is identifying potential targets along the aggregation pathway and understanding the factors that influence disease progression. Over the years, experimental and theoretical biologists, chemists, and physicists have studied the underlying mechanisms of protein misfolding and aggregation to better understand the disease etiology. Researchers across the globe are attempting to clarify the fundamentals of protein misfolding, which has been the focus of intense basic and clinical research.
This Special Issue, entitled “Research Advances in Protein Misfolding”, invites researchers committed to understanding the underlying mechanism of protein misfolding diseases at a molecular, cellular, and animal model to submit their recent work addressing this fascinating topic.
Dr. Bikash Sahoo
Guest Editor
Manuscript Submission Information
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Keywords
- protein misfolding
- amyloids
- neurodegenerative diseases
- proteostasis
- protein aggregation
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