Recent Advances in Novel Metabolic Engineering Approaches for Producing Novel Chemicals
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: closed (25 May 2024) | Viewed by 417
Special Issue Editor
Special Issue Information
Dear Colleagues,
Due to the scarcity of non-renewable energy sources, there is an increasing focus on microbial cell factories to produce chemicals, materials, and more generally value-added compounds from renewable non-food biomass, rather than traditional chemical production. Metabolic engineering is thus the backbone of the bioeconomy, in which industrial chemical products from renewable feedstocks by microbial cell factories provide a promising avenue toward sustainability.
In fact, microorganisms have great potential because they can naturally produce many different metabolites that we need. However, compound yields from native or transformed microorganisms can be low and often require genetic modification to produce microorganisms where yields can effectively compete with classical production of chemically engineered molecules. That's why, for the past 30 years, metabolic engineering strategies have focused on improving metabolic performance in every possible way to obtain industrially tailored microbes. Recently, Rapid technological progress in gene assembly, biosensors, and genetic circuits have led to reinforcing the cellular synthetic capacity for chemical production.
This special issue will focus on recent advances and breakthroughs in the strategy for microbial cell engineering to improve the cellular synthetic capacity by utilizing biotechnological tools along with system biology methods to regulate cellular functions during chemical production. We invite original research articles, research exchanges, and comprehensive reviews on metabolic engineering strategies using synthetic biology tools.
Prof. Dr. Xiulai Chen
Guest Editor
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Keywords
- metabolic engineering
- genome engineering
- synthetic metabolic pathways
- biosynthesis
- microbial biotechnology
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