Neural Stem Cells: Focusing on Disease Modeling and Translational Application 2.0

Dear Colleagues, 

The aim of this issue is to bring together international experts to provide both comprehensive overviews for and original contributions to this dynamic research field. During the last century, the progress in neural stem cell biology has revolutionized the way we study and treat diseases, transforming both the fields of science and medicine.

The present issue focuses on the use of neural stem cells (derived from different sources, including iPSC) in basic and translational research, starting from the cellular models necessary to define the mechanisms underlying neurodegenerative/neurodevelopmental diseases, and progressing to preclinical studies and drug screening approaches.

This Special Issue includes the following contributions:

1. The strategies adopted to direct the differentiation of neural stem cells and define disease models;
2. The variety of pathological mechanisms that could be addressed by these approaches;
3. The methodologies used to screen candidate compounds, validate their efficacy, and accelerate drug development;
4. The preclinical studies allowing for the translation of the scientific knowledge obtained through neural stem cells into potential therapeutic treatments.

The present issue is also open to the individuals working in the area of multidisciplinary studies, who create materials or use technologies to convey the cells to the injection site, improving both their engraftment and differentiation.

Dr. Jessica Rosati
Dr. Daniela Ferrari
Prof. Dr. Angelo Luigi Vescovi
Guest Editors

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• neural stem cells
• disease models
• neurodegenerative/neurodevelopmental disease
• pathological mechanism dissection
• biomaterials
• drug screening