Pesticide Exposure and Toxicity Research: Impacts on Endocrine and Nervous System Pathophysiology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 63
Special Issue Editor
2. Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina
Interests: pesticides; reproduction; risk assesment; epigenetics; endocrine disruption
Special Issue Information
Dear Colleagues,
Pesticide exposure is a significant concern due to the chemicals’ widespread use in agriculture, public health, and pest control. This Special Issue, entitled “Pesticide Exposure and Toxicity Research: Impacts on Endocrine and Nervous System Pathophysiology”, welcomes research on the impacts of pesticides on human and environmental health, including different experimental model studies. Pesticides, though effective in pest management, can lead to varied acute and chronic health issues in humans, including neurotoxic, carcinogenic, endocrine-disrupting, and reproductive effects. Notably, increasing evidence points to the involvement of pesticides in the pathophysiology of the nervous system, contributing to neurodevelopmental delays, neurodegenerative processes, and synaptic dysfunctions. The mechanisms of action vary depending on the chemical class of the pesticide, with most acting by inhibiting key biological pathways such as acetylcholinesterase activity or disrupting hormone regulation. This Special Issue also includes the challenges involved in assessing the risks associated with pesticide exposure, including the variability in human susceptibility, the complexity of exposure scenarios, and the limitations of current testing models. Risk assessment methods are explored, focusing on exposure estimation, toxicity data, and safety margins, while highlighting the importance of improving regulatory standards and surveillance systems to protect vulnerable populations. In conclusion, this Special Issue underscores the need for a more integrated approach to understanding pesticide risks, including enhanced biomonitoring, toxicological research, and the study of mechanisms of action, particularly those affecting the nervous system.
Dr. Jorgelina Varayoud
Guest Editor
Manuscript Submission Information
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Keywords
- pesticide exposure
- neurotoxicity
- endocrine disruption
- risk assessment
- toxicological mechanisms
- human health effects
- biomonitoring
- animal models
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