Synthesis and Characterization of Bicyclam Compounds
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 267
Special Issue Editor
Special Issue Information
Dear Colleagues,
Bicyclam compounds, or bis-tetraazamacrocycles, consist of two cyclam rings linked by an aliphatic or aromatic bridge. Among other potential uses, bicyclams have potential therapeutic use due to their interaction with the CXCR4 chemokine receptor in the human body. Initially thought to be an impurity in commercially available cyclam samples, the bicyclam known as JM1657 was found to have anti-human immunodeficiency virus (anti-HIV) activity. Although synthesis of the original bicyclam impurity has since remained elusive, synthetic methods were developed to create various derivatives of the original compound. As such, a wide variety of bicyclam analogues have since been synthesized, with various alterations being made to the original structure, including the introduction of aliphatic bridges to change the configuration, aromatic linkers between rings, and complexation with different metals, to name just a few. Characterization of bicyclam analogues can be accomplished with a variety of different techniques; some of these, including growing crystals suitable for analysis, have remained quite challenging. This Special Issue will explore a collection of research papers and reviews detailing various schemes for bicyclam analogue synthesis, characterization techniques used to analyse these macrocycles, the molecular interactions that present challenges in bicyclam characterization, and the strategies employed to overcome these obstacles.
Dr. Randall D. Maples
Guest Editor
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Keywords
- bicyclam analogues
- tetraazamacrocycle
- macrocycle–metal ion interactions
- anti-HIV
- CXCR4 co-receptor
- white blood cell mobilization
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