Gut Microbiota in Disease and Health 3.0

Dear Colleagues,

This Special Issue is a continuation of our previous successful issue “Gut Microbiota in Disease and Health 2.0”.

The gut microbiota is a diverse microbial ecosystem that is dominated by bacteria but also includes populations of fungi, viruses, archaea, and protists. It seems to have coevolved with humans for a mutually beneficial coexistence, being essential in certain complementary metabolic activities that have not fully evolved in the human host. The advent of high-throughput next-generation sequencing platforms, the integration of multi-omics data, and bioinformatics development have accelerated the gaining of knowledge about gut microbial community composition, creating a tremendously shifting our knowledge of physiopathological processes. However, the functions of these communities and how they interact with the host are not fully understood. Since gut bacteria are physically separated from the intestinal epithelium by a mucus layer, without direct interactions between them, the aims of this Special Issue is to delineate the molecular mechanisms by which the gut microbiota affects host metabolism in a paracrine or endocrine manner. We also aim to focus on gut microbiota modulation to promote health and prevent disease. Several strategies have been explored to modulate gut microbiota, from dietary changes, prebiotics, probiotics, antibiotics, to more advanced interventions such as fecal transplantation, bacteriophages, or gene editing therapies. Deepening our knowledge of the molecular mechanisms of gut microbiota/host interactions and emerging modulation strategies offer new opportunities to understand and manipulate the gut microbiota for the benefit of human health.

Dr. Javier Modrego
Dr. Dulcenombre Gómez Garre
Guest Editors

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