Advanced Research on Sulfatases and Sulfotransferases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (10 March 2024) | Viewed by 341
Special Issue Editor
Interests: glycosaminoglycan sulfatases; sulfotransferases; steroid and other sulfatases; metabolic pathways affected by sulfation; impact of changes in sulfation in disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The identification of the roles played by sulfatases, sulfotransferase enzymes, and sulfated glycosaminoglycans (GAGs) in signaling, transcription, and cell differentiation has focused on the mechanisms of action in well-defined biological systems. Together, sulfatases, sulfotransferases, and sulfated GAGs confer remarkable specificity in the regulation of vital processes in plants, microbiota, and macrobiota. By the post-translational modification of carbohydrates, including glycosaminoglycans, lipids, proteins, and steroids, sulfation influences interactions within and between cells and in response to the extracellular environment. Thus, changes in sulfation affect subsequent phosphorylations and other post-translational events. The specific, chemically precise recognition signals attributable to localized sulfates can influence vital cell processes in immunity and host cell responses to infection, as well as in the activation/inactivation of steroid hormones, coagulation, drug metabolism, and cell signaling. The complex biochemistry required for the removal or addition of sulfate residues reflects the importance of molecular recognition and the potential harm of molecular mimicry, such as by the food additive carrageenan, to disrupt homeostatic mechanisms. The articles in this Special Issue will reveal the range of effects of sulfation, outline what is known about the underlying molecular and biochemical pathways, and suggest avenues for future investigations.
Dr. Joanne Tobacman
Guest Editor
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Keywords
- sulfatase
- sulfotransferase
- heparin
- chondroitin sulfate
- sulfated glycosaminoglycans (GAGs)
- sulfation
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