Research in Progression of Alzheimer’s Disease and Atherosclerosis
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Global Health".
Deadline for manuscript submissions: closed (15 February 2022) | Viewed by 681
Special Issue Editor
Special Issue Information
Dear Colleagues,
The World Alzheimer Report 2018 states that 50 million people worldwide are living with dementia, and this number will more than triple to 152 million by 2050. The total estimated worldwide cost of dementia in 2018 was one trillion US dollars and is expected to rise to two trillion US dollars by 2030. Although the understanding of the neurobiology and pathogenesis of Alzheimer’s disease (AD), the most common form of dementia, has recently been greatly increased, only a few symptomatic treatments are currently available, and no curative treatment has been developed. Thus, parallel to the effort towards the development of drugs for the treatment of AD, efforts to develop preventive therapeutic strategies, such as nutritional therapies and caloric restriction, have been extensively investigated and implemented.
Recent studies discovered a possible common pathogenic background for AD and atherosclerosis. This include, for example, apolipoprotein‐E (ApoE). ApoE is protective against atherosclerosis and lipid plaque formation in the aorta by accepting remnant lipoproteins and promoting their uptake into the liver for clearance. Evidence also indicates that people with the apoE4 allele are susceptible to late-onset AD.
This Special Issue will focus on advances in the field of AD and atherosclerosis. Studies that could shed light on the pathogenesis, development of drugs, diagnosis, and prognosis of AD and atherosclerosis are welcome.
Prof. Dr. Eunyoung Ha
Guest Editor
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Keywords
- Alzheimer’s disease
- Atherosclerosis
- Lipoprotein
- Apoprotein-E
- Inflammation
- Aging
- Senescence
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