Special Issue "Endocrine Disruptor Chemicals and Estrogenic Activity in the Context of Health Risk Assessment"
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Health".
Deadline for manuscript submissions: 28 February 2021.
Interests: endocrine disruptors; estrogenic activity; E-screen; gene reporter assay; particulate matter; air pollution; PM10; PM2.5; biomonitoring; effect based monitoring tools; mutagenicity; genotoxicity; comet assay; Ames test; risk assessment; health risk assessment
Interests: mycology, microbial interactions, ex situ conservation, biobanks, bioremediation, ecotoxicology, circular economy
The World Health Organization defines endocrine-disrupting chemicals (EDCs) as “exogenous substances or mixtures that alter function(s) of the endocrine system and consequently cause adverse health effects in an intact organism, or its progeny, or (sub) populations”. EDCs are a highly heterogeneous group of natural and synthesized chemicals, which are ubiquitous in the environment. Human exposure to them occurs through different ways, such as inhalation, ingestion of contaminated food and/or water, and dermal contact by the use of personal care products.
EDCs can alter the functions of different natural hormones; they can act directly on hormone receptors as agonists or as antagonists or indirectly interfering with synthesis, transport, metabolism, and excretion of hormones. Exposure to low doses of EDCs is enough to induce effects, and the exposure during specific life time periods can induce permanent adverse effects.
Traditional assessment of EDCs, based on identifying and quantifying individual chemicals, has some limitations: it is performed considering specific known substances and cannot quantify the effect of unknown or unconsidered compounds, and the cumulative effects of a mixture cannot be directly concluded from individual EDC levels as synergistic/antagonistic interactions are not considered. In addition to the chemical assessment, biological monitoring represents a key element. It is performed through effect-based tools which are able to evaluate the total effect induced by numerous, bioavailable chemicals with the same mechanism of action. In particular, the estrogenic activity of environmental or biological samples has been proposed and utilized as an EDC exposure biomarker.
Prof. Tiziana Schilirò
Dr. Giovanna Di Nardo
Dr. Cinzia La Rocca
Prof. Giovanna Cristina Varese
Manuscript Submission Information
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- Endocrine-disrupting compounds
- Estrogenic activity
- Low-dose exposure
- Environmental risk assessment
- Health risk assessment