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A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Infectious Diseases, Chronic Diseases, and Disease Prevention".

Deadline for manuscript submissions: closed (14 March 2025) | Viewed by 5681

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Prof. Dr. David Carabantes-Alarcón

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Guest Editor

Department of Public Health and Maternal & Child Health, Faculty of Medicine, IdISSC, Universidad Complutense de Madrid, 28040 Madrid, Spain
Interests: diabetes mellitus; health education; statistics and numerical data

Special Issue Information

Dear Colleagues,

Diabetes mellitus is a very prevalent disease that results in high costs to health systems and important morbidity and mortality. Investigation into diabetes is needed in order to reduce its incidence and complications and to improve the quality of life of the persons affected by this condition. New advances in diabetes imply studies in genetics, etiology, treatments, and monitoring. Furthermore, more epidemiological and basic investigations are necessary. Future advances include the design and application of novel remote sensing and information technology. The application of new statistical and artificial intelligence techniques will make it possible to analyze the data obtained from empirical research. The evaluation of diabetes can also provide important information for the design of future education programs. Globally, diabetes is among the top 10 causes of death.

Given the importance of diabetes, the International Journal of Environmental Research and Public Health (IJERPH) is launching a Special Issue entitled “New advances in diabetes” with the aim of gathering accurate and up-to-date scientific information on all aspects of diabetes.

We are pleased to invite you and your co-workers to submit original research articles and review articles aimed at providing a comprehensive overview of the advances in the understanding and treatment of this disease.

Prof. Dr. David Carabantes-Alarcón
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

diabetes mellitus
therapeutics
blood glucose self-monitoring
wearable electronic devices
etiology
mortality
prevention and control
statistics and numerical data
pregnancy in diabetics
health education

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Published Papers (4 papers)

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Research

Jump to: Review, Other

14 pages, 656 KiB

Open AccessArticle

Homozygous AA Genotype of IL-17A and 14-bp Insertion Polymorphism in HLA-G 3′UTR Are Associated with Increased Risk of Gestational Diabetes Mellitus

by Amaxsell Thiago Barros de Souza, Cecília Rodrigues Lucas, Kleyton Thiago Costa de Carvalho, Antonia Pereira Rosa Neta, Emanuelly Bernardes-Oliveira, Juliana Dantas de Araújo Santos Camargo, André Ducati Luchessi, Ricardo Ney Cobucci and Janaina Cristiana de Oliveira Crispim

Int. J. Environ. Res. Public Health 2025, 22(3), 327; https://doi.org/10.3390/ijerph22030327 - 22 Feb 2025

Viewed by 622

Abstract

Gestational diabetes mellitus (GDM) is a common pregnancy complication characterized by hyperglycemia and insulin resistance, with unclear genetic mechanisms. The specific involvement of proinflammatory cytokines, including IL-17A, and the immuno-tolerogenic HLA-G remains poorly understood in GDM. We aimed to explore the associations of three polymorphisms, IL-17A -197G>A (rs2275913), IL-17RA -947A>G (rs4819554), and HLA-G 14-bp insertion/deletion (indel), with GDM risk in a Brazilian population. We conducted a case-control study (79 GDM cases and 79 controls). Genetic polymorphisms were analyzed using PCR–RFLP, with DNA extracted using the Salting-out procedure. Significant associations were identified between -197G>A rs2275913 and HLA-G 14-bp indel polymorphisms in both codominant and recessive models. The IL-17A rs2275913 AA genotype was associated with a nearly ten-fold increased risk of GDM in both the codominant (p = 0.021, OR 9.89, 95% CI: 1.63–59.92) and recessive models (p = 0.006, OR 9.33, 95% CI: 1.57–55.38). Similarly, the HLA-G 14-bp Ins/Ins genotype was associated with an increased risk in both the codominant (p = 0.026, OR 3.34, 95% CI: 0.98–11.41) and recessive models (p = 0.010, OR 4.20, 95% CI: 1.36–12.96). IL-17RA polymorphism showed no significant associations. The study findings highlight the potential genetic and immune factors associated with GDM, particularly the -197G>A rs2275913 and HLA-G 14-bp indel polymorphisms. Further functional characterization is warranted to uncover the mechanism of genotype–phenotype association. Full article

(This article belongs to the Special Issue New Advances in Diabetes)

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14 pages, 388 KiB

Open AccessArticle

Use of Cardiac Procedures in People with Diabetes during the COVID Pandemic in Spain: Effects on the In-Hospital Mortality

by Ana Lopez-de-Andres, Rodrigo Jimenez-Garcia, David Carabantes-Alarcon, Valentín Hernández-Barrera, José M. de-Miguel-Yanes, Javier de-Miguel-Diez, Jose J. Zamorano-Leon, Jose L. del-Barrio and Natividad Cuadrado-Corrales

Int. J. Environ. Res. Public Health 2023, 20(1), 844; https://doi.org/10.3390/ijerph20010844 - 2 Jan 2023

Cited by 2 | Viewed by 1969

Abstract

We aimed to assess the effect of the COVID-19 pandemic in Spain on people with diabetes undergoing cardiac procedures, such as coronary artery bypass graft (CABG), percutaneous coronary intervention (PCI), open surgical valve replacement (OSVR), and transcatheter valve implantation (TCVI). We compared the year 2019 with the year 2020. We conducted an observational study using data from the Spanish National Hospital Discharge Database from 1 January 2019 to 31 December 2020. In 2020, a total of 21,067 cardiac procedures were performed on people with diabetes compared with 24,675 in the previous year. The use of CABG, PCI, OSVR and TCVI decreased from 2019 to 2020 by 13.9%, 14.8%, 21.4% and 2.9%, respectively. In 2020, patients had a significantly higher mean Charlson Comorbidity Index than in 2019 for all the cardiac procedures analyzed. In-hospital mortality (IHM) was higher (p > 0.05) for all the procedures in the year 2020. Over the entire period, female sex was a significant risk factor for IHM among those who underwent CABG, PCI and OSVR (OR 1.94, 95%CI 1.41–2.66; OR 1.19, 95%CI 1.05–1.35; and OR 1.79, 95%CI 1.38–2.32, respectively). The sensitivity analysis including two more years, 2017 and 2018, confirmed that female patients and comorbidity were risk factors for IHM in patients with diabetes regardless of whether it was during the pandemic era or before. We conclude that the frequency of cardiac procedures among people with diabetes declined in 2020. IHM did not change significantly in the COVID-19 era. Full article

(This article belongs to the Special Issue New Advances in Diabetes)

Review

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30 pages, 6863 KiB

Open AccessReview

Global Trends in Diabetic Foot Research (2004–2023): A Bibliometric Study Based on the Scopus Database

by Yolanda Fuentes-Peñaranda, Alma Labarta-González-Vallarino, Elena Arroyo-Bello and Marina Gómez de Quero Córdoba

Int. J. Environ. Res. Public Health 2025, 22(4), 463; https://doi.org/10.3390/ijerph22040463 - 21 Mar 2025

Viewed by 633

Abstract

Diabetic foot is one of the leading complications of diabetes mellitus that affects millions of people around the world and involves the presence of ulcers, infections, tissue destruction, and loss of sensation and can even lead to limb amputation. This research explores trends in diabetic foot global research through a bibliometric analysis of publications indexed in Scopus in the period 2004–2023. A total of 7136 documents were analysed using Excel, Python, Biblioshiny, and VOSviewer. Scientific production has multiplied by a factor of 6.6 from the first to the last year analysed. Armstrong D.G. is the most productive and cited author. China is the most productive country, and the United States is the most cited. The most productive journal is the International Journal of Lower Extremity Wounds, and the most cited journal is Diabetes Care. Research on diabetic foot is mainly focused on the complications of diabetes mellitus; the treatment and healing of wounds; infections; and epidemiology and patient care. Infections and antibiotic treatment are emerging topics, while deep learning and machine learning are among the niche topics in this area of knowledge. The present study allows us to identify current trends and future directions of research in diabetic foot. Full article

(This article belongs to the Special Issue New Advances in Diabetes)

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Other

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9 pages, 1229 KiB

Open AccessBrief Report

Aerobic Exercise in the Aquatic Environment Suppresses the Plasma Renin Activity in Individuals with Type 2 Diabetes: A Secondary Analysis of a Randomized Clinical Trial

by Rodrigo Sudatti Delevatti, Larissa dos Santos Leonel, João Gabriel da Silveira Rodrigues, Ana Carolina Kanitz, Cristine Lima Alberton, Gisele Agustini Lovatel, Ionara Rodrigues Siqueira and Luiz Fernando Martins Kruel

Int. J. Environ. Res. Public Health 2024, 21(7), 938; https://doi.org/10.3390/ijerph21070938 - 18 Jul 2024

Viewed by 1462

Abstract

To compare the acute effects of aquatic walking/running versus dry-land walking/running on blood glucose and plasma renin activity (PRA) in individuals with type 2 diabetes, participants with type 2 diabetes performed deep-water or dry-land walking and/or running sessions in a swimming pool or on an athletics track, respectively. Both sessions comprised seven blocks of 3 min at 85–90% of the heart rate deflection point (HRDP), interspersed with 2 min at <85% HRDP, totaling 35 min, with a 48 h interval between sessions. PRA and blood glucose were assessed before and immediately after the sessions. Generalized estimation equations were used to verify the session effects, with the Bonferroni post hoc test, considering the significance level as 0.05. Twelve individuals (53.2 ± 8.9 years) diagnosed with type 2 diabetes for 6.3 ± 6.34 years participated in the study. A reduction in PRA was found only after the aquatic session (−7.75 ng/mL/h; −69%; p: 0.034), while both aquatic and dry-land sessions similarly reduced the blood glucose levels (aquatic: −38 mg/dL, −21%; dry-land: −26 mg/dL, −14%; time effect, p = 0.007). Despite yielding similar glycemic reductions as dry-land walking/running, aquatic walking/running led to an expressive decrease in PRA among individuals with type 2 diabetes. Full article

(This article belongs to the Special Issue New Advances in Diabetes)

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