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Oral Health: The Key to a Healthy Smile?

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Oral Health".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1481

Special Issue Editor


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Guest Editor
School of Dental Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia
Interests: epigenetic markers in oral diseases; type 2 diabetes mellitus; COVID-19; bioethics; antibiotic stewardship

Special Issue Information

Dear Colleagues,

Epidemiologic and clinical studies strongly suggest the critical importance of oral health to systemic health. Nevertheless, the misconception that oral health care is not an essential health service and is thus a matter of choice rather than necessity was present among general public and public health experts until recently. Namely, in November 2022, the WHO, in its global strategy on oral health, proposed universal oral health coverage for all people by 2030, by means that “every individual has access to essential, quality health services that respond to their needs and which they can use without suffering financial hardship”. Oral health crisis is linked to another global health problem, antimicrobial resistance, and dentists could help by becoming involved with collaborative antimicrobial stewardship. Oral health is integral to overall health, well-being, and optimal quality of life. Oral diseases share modifiable risk factors common to the leading noncommunicable diseases, such as tobacco use, alcohol use, high sugar intake, and the human papilloma virus infection, all related to cardiovascular disease, type 2 diabetes mellitus, and cancer. These facts impose that patient-tailored oral health strategies need to be integrated within appropriate overall health agenda. Such tailored diagnosis/treatment relies on the close collaboration of dental experts and doctors of other medical specialties as well as the introduction of supplemental tools to improve the precision of diagnosis, treatment planning, and prediction of treatment results, such as artificial intelligence (AI)-based systems. The COVID-19 pandemic had a negative impact on the provision of oral health services, leading to oral health deterioration, increased antibiotic prescriptions, and greater oral health inequalities. However, data are scarce on oral health management in the post-COVID-19 era. Therefore, dental and general public health research activities and initiatives aiming at oral health promotion and oral disease prevention as well as the introduction of new strategies, such as AI-based systems use, are needed.

Dr. Jelena R. Roganović
Guest Editor

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Keywords

  • oral health promotion
  • oral diseases
  • quality of life
  • type 2 diabetes mellitus
  • cardiovascular disease
  • COVID-19
  • artificial intelligence
  • antibiotic stewardship

Published Papers (1 paper)

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Research

12 pages, 2280 KiB  
Article
Melatonin Action in Type 2 Diabetic Parotid Gland and Dental Pulp: In Vitro and Bioinformatic Findings
by Milena Barać, Milan Petrović, Nina Petrović, Nataša Nikolić-Jakoba, Zoran Aleksić, Lidija Todorović, Nataša Petrović-Stanojević, Marina Anđelić-Jelić, Aleksandar Davidović, Jelena Milašin and Jelena Roganović
Int. J. Environ. Res. Public Health 2023, 20(18), 6727; https://doi.org/10.3390/ijerph20186727 - 7 Sep 2023
Viewed by 1220
Abstract
Type 2 diabetes mellitus (T2DM) is associated with functional deterioration of the salivary gland and dental pulp, related to oxidative stress. The aim was to integrate experimental and bioinformatic findings to analyze the cellular mechanism of melatonin (MEL) action in the human parotid [...] Read more.
Type 2 diabetes mellitus (T2DM) is associated with functional deterioration of the salivary gland and dental pulp, related to oxidative stress. The aim was to integrate experimental and bioinformatic findings to analyze the cellular mechanism of melatonin (MEL) action in the human parotid gland and dental pulp in diabetes. Human parotid gland tissue was obtained from 16 non-diabetic and 16 diabetic participants, as well as human dental pulp from 15 non-diabetic and 15 diabetic participants. In human non-diabetic and diabetic parotid gland cells (hPGCs) as well as in dental pulp cells (hDPCs), cultured in hyper- and normoglycemic conditions, glial cell line-derived neurotrophic factor (GDNF), MEL, inducible nitric oxide synthase (iNOS) protein expression, and superoxide dismutase (SOD) activity were measured by enzyme-linked immunosorbent assay (ELISA) and spectrophotometrically. Bioinformatic analysis was performed using ShinyGO (v.0.75) application. Diabetic participants had increased GDNF and decreased MEL in parotid (p < 0.01) and dental pulp (p < 0.05) tissues, associated with increased iNOS and SOD activity. Normoglycemic hDPCs and non-diabetic hPGCs treated with 0.1 mM MEL had increased GDNF (p < 0.05), while hyperglycemic hDPCs treated with 1 mM MEL showed a decrease in up-regulated GDNF (p < 0.05). Enrichment analyses showed interference with stress and ATF/CREB signaling. MEL induced the stress-protective mechanism in hyperglycemic hDPCs and diabetic hPGCs, suggesting MEL could be beneficial for diabetes-associated disturbances in oral tissues. Full article
(This article belongs to the Special Issue Oral Health: The Key to a Healthy Smile?)
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