Opportunities and Challenges in Multiple Myeloma Treatment and Management

A special issue of Hematology Reports (ISSN 2038-8330).

Deadline for manuscript submissions: closed (30 May 2023) | Viewed by 2227

Special Issue Editors

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Guest Editor
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, 47014 Meldola, Italy
Interests: acute lymphoblastic leukemia; acute myeloid leukemia; myelodysplastic syndromes; multiple myeloma and MGUS; non-Hodgkin and Hodgkin lymphoma
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Special Issue Information

Dear Colleagues,

Multiple myeloma (MM) is a hematological malignancy characterized by a high propensity for recurrence and drug resistance. A wide range of genetic and epigenetic abnormalities have been implicated in the pathogenesis of this cancer, ultimately affecting the growth, survival and drug sensitivity of multiple myeloma cells.

Although many therapeutic agents have been developed to improve the depth and duration of response and prolong patient survival, the management of multiple myeloma remains challenging due to the eventual emergence of drug-resistant clones and often imminent relapse. These events have prompted continued research to identify new molecular lesions and therapeutic targets, with the ultimate goal of finding a cure for multiple myeloma.

Therefore, this special issue focuses on the tumor microenvironment and mechanisms of deterioration, i.e. drug resistance, proliferative signaling, immune evasion, etc., which are involved in the aggressive disease behavior of refractory MM, to better manage those that develop into new tumors. treatment strategy.

Dr. Claudio Cerchione
Dr. Giovanni Martinelli
Guest Editors

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  • multiple myeloma
  • hematological malignancy
  • drug resistance
  • tumor microenvironment

Published Papers (1 paper)

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7 pages, 661 KiB  
Case Report
A Report of a Symptomatic Progressive Myeloma during Pregnancy and Postpartum Period from Asymptomatic State
by Gehad Elgabry, Lydia Spencer, Hisam Siddiqi, Soumya Ojha and Farooq Wandroo
Hematol. Rep. 2023, 15(2), 305-311; https://doi.org/10.3390/hematolrep15020031 - 5 May 2023
Viewed by 1673
 Multiple myeloma is a plasma cell malignancy that is most commonly observed in males in the sixth and seventh decade of life. The clinical scenario of multiple myeloma with concurrent pregnancy is considered to be very rare. We detail here the case [...] Read more.
 Multiple myeloma is a plasma cell malignancy that is most commonly observed in males in the sixth and seventh decade of life. The clinical scenario of multiple myeloma with concurrent pregnancy is considered to be very rare. We detail here the case of a young female with known IgG kappa multiple myeloma who was found to have a steady elevation of her IgG kappa paraprotein during pregnancy and symptomatic progression in the postpartum period. She delivered a healthy baby at 40 weeks gestation. We present a review of all reported cases of known multiple myeloma progressing during pregnancy and in the postpartum period, the treatments given, and their outcomes. The report also provides suggestions for diagnosis and management of myeloma during pregnancy in order to have an outcome of successful uncomplicated pregnancy with healthy offspring.  Full article
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