Challenges in the Treatment of Myelodysplastic Syndrome
A special issue of Hemato (ISSN 2673-6357). This special issue belongs to the section "Chronic Myeloid Disease".
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 34500
Special Issue Editors
Interests: myelodyspalstic syndromes; acute and chronic myeloid leukemias
2. Bone Marrow Transplantation Department, French Reference Center for Aplastic Anemia and PNH, Paris, France
Interests: allogeneic stem cell transplantation; graft-versus-host disease; immune defect and other post-transplant complications; myelodysplastic syndrome; myeloproliferative disorders; aplastic anemia
Special Issue Information
Dear Colleagues,
This Special Issue is dedicated to “MDS from Bench to Bedside”, and is conceived under the direction of Pierre Fenaux who has made efforts to continuously contribute to the field over the last 35 years.
During the last decade, the explosion of molecular techniques has enabled better understanding of MDS and AML pathogenetic mechanisms, clonal heterogeneity, and individual diversity. Based on recent findings, new MDS entities have emerged. Alterations in hematopoietic processes, from clonal hematopoiesis of indeterminate potential to lower- and higher-risk MDS have been characterized and analyzed. Molecular signatures of MDS have been used to identify innovative and effective target therapy. While stem cell transplant is still the only curative approach for MDS, combining therapies with different targets and mechanisms of action may be promising to relieve symptoms related to MDS or to decrease the risk of progression to AML.
In this Special Issue, we aim to highlight some of the most important and topical issues, including recent advances, controversies, and challenges in the treatment of MDS.
Prof. Dr. Valeria Santini
Dr. Marie Robin
Guest Editors
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Keywords
- MDS
- genomic
- targeted therapy
- transplantation
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