Special Issue "Imaging Vascular Infection and Inflammation by FDG-PET/CT or Radiolabelled White Blood Cells"

A special issue of Hemato (ISSN 2673-6357). This special issue belongs to the section "Radiolabeled Blood Elements and Other Imaging Modalities".

Deadline for manuscript submissions: 30 June 2023 | Viewed by 140

Special Issue Editors

Department of Surgical-Medical Sciences and Translational Medicine, University of Rome “Sapienza”, Rome, Italy
Interests: nuclear medicine; infection imaging; inflammation imaging; thyroid cancer imaging; pre-clinical imaging; imaging immuno-therapy; imaging autoimmune diseases
Special Issues, Collections and Topics in MDPI journals
Division of Nuclear Medicine, Department of Oncology and Advanced Technology, S.Maria Nuova Hospital, AUSL-IRCCS (Research Cancer Institute) of Reggio Emilia, Viale Risorgimento, 80 42123 Reggio Emilia, Italy
Interests: nuclear medicine; PET/CT; inflammation/infection imaging; thyroid cancer imaging and therapy; neuroendocrine tumor imaging and therapy; lymphoma imaging; multiple myeloma imaging

Special Issue Information

Dear Colleagues,

This Special Issue aims at providing a panoramic overview of current and future strategies for imaging vascular infections and inflammation. Both conditions still represent a challenge for clinicians and require a prompt diagnosis and initiation of adequate treatment.

Nuclear medicine imaging has rapidly gained a role in the field of infection and inflammation, and it is currently included in most of the diagnostic flowcharts for the diagnosis of vasculitis, vascular graft infections and cardiovascular infections. For some of these indications, specific interpretation criteria, able to allow an accurate diagnosis, have been published for both [18F]FDG PET/CT and radiolabelled white blood cells scintigraphy, thereby improving therapy planning; for some other clinical indications, standardized protocols of image acquisition and interpretation are still needed and deserve further prospective and comparative studies.

This Special Issue will be, therefore, focused on the possible application of [18F]FDG PET/CT and radiolabelled white blood cells scintigraphy for imaging atherosclerosis, vasculitis, vascular graft infections and other haematological conditions. In particular, it will collect papers exploring the potential of nuclear medicine imaging in the diagnostic setting of these situations as well as for monitoring disease activity after a proper treatment.

Prof. Dr. Alberto Signore
Dr. Annibale Versari
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Hemato is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • FDG
  • PET-CT
  • radiolabelled white blood cells
  • atherosclerosis
  • vasculitis
  • vascular grafts
  • inflammation
  • infection
  • haematological disorders

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1.Type of the paper: Review
Tentative title: Labeled leukocyte imaging of intracavitary prosthetic vascular graft infections
Authors: Christopher J. Palestro, M
Department of Radiology Zucker School of Medicine at Hofstra/Northwell,Hempstead, New York USA

Abstract: Although prosthetic vascular graft infections are uncommon, they are associated with a high morbidity and, in some situations, mortality. Prosthetic vascular grafts in the thorax and abdomen are referred to as intracavitary grafts. The clinical presentation of these infections depends on the graft location, pathogenesis of the infection, and the interval since surgery. Thoracic infections involving the aortic root can mimic infective endocarditis and typically occur within 3 months of surgery. Abdominal vascular graft infections usually develop months to years after placement. Symptomatic patients may present with abdominal pain, fever, sepsis, and, when there is erosion into the bowel, gastrointestinal bleeding.

The sensitivity of labeled leukocyte imaging, which has been used for diagnosing these infections for many years, ranges from about 70% to 100% and is not affected by duration of symptoms or antibiotic treatment. Specificity ranges from about 80% to 100%. SPECT/CT improves both the sensitivity and specificity and is especially useful for detecting, localizing, and defining the extent of infection. 

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