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Healthcare
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The Role of Nutrition in Metabolic Dysfunction-Associated Steatotic Liver Disease
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The Role of Nutrition in Metabolic Dysfunction-Associated Steatotic Liver Disease

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Clinical Care".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1315

Special Issue Editor

Prof. Dr. Omar Ramos-Lopez

E-Mail Website
Guest Editor
Medicine and Psychology School, Autonomous University of Baja California, Tijuana 22390, Mexico
Interests: nutrition; obesity; diet; chronic diseases; genetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common cause of chronic liver disease in most countries. Malnutrition (undernutrition and overnutrition) plays a pivotal role in the onset and progression of MASLD. Also, innovative dietary therapies, including those based on caloric restriction and nutrient modification or bioactive food compound supplementation, could contribute to the precise management of MASLD. This Special Issue covers epidemiological and observational evidence about the implication of nutrition on the prevalence of MASLD. Clinical trials focused on the use of dietary interventions for the treatment of MASLD are encouraged. Comprehensive reviews covering the most important advances concerning the interplay of nutrition in MASLD are also welcome.

Prof. Dr. Omar Ramos-Lopez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • MASLD
  • liver disease
  • nutrition
  • diet
  • nutrients

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Published Papers (1 paper)

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Research

11 pages, 426 KB  
Article
Positive Association of the Dietary n-6/n-3 PUFA Ratio with Fatty Liver in Mexican Adults
by Cristina Gutierrez-Osorio and Omar Ramos-Lopez
Healthcare 2025, 13(21), 2679; https://doi.org/10.3390/healthcare13212679 - 23 Oct 2025
Viewed by 1013
Abstract
Background: The increase in obesity rates and related liver diseases has risen in recent years in Mexico. Dietary factors, such as the imbalance between n-6 and n-3 polyunsaturated fatty acids, have been associated with a higher risk of developing conditions such as fatty [...] Read more.
Background: The increase in obesity rates and related liver diseases has risen in recent years in Mexico. Dietary factors, such as the imbalance between n-6 and n-3 polyunsaturated fatty acids, have been associated with a higher risk of developing conditions such as fatty liver. The objective of this study was to analyse the influence of the dietary n-6/n-3 ratio on fatty liver in Mexican adults. Methods: This analytical cross-sectional study included 213 Mexican adults aged 18 to 65 years, of both genders. The dietary n-6/n-3 ratio was calculated using the Nutritionist Pro software. Participants were divided into two groups according to the median of their dietary n-6/n-3 intake ratio: “low” (<10.2:1) and “high” (≥10.2:1). Anthropometric and biochemical markers were evaluated using standardised methods. The hepatic steatosis index (HSI) was used as a surrogate marker of fatty liver. Multivariate logistic regression analyses were conducted to predict fatty liver based on HSI. Results: Overall, the mean dietary n-6/n-3 ratio was 12.75 in the general population. Higher HSI values were found in participants with a high n-6/n-3 ratio (p = 0.038). In the multivariate model, the n-6/n-3 ratio was positively associated with high HSI (OR = 1.48, 95% CI, 1.02, 1.99). Conclusions: This study concludes that a high n-6/n-3 ratio may contribute to the development of fatty liver in Mexican adults. These results highlight the importance of a balanced intake of fatty acids to prevent metabolic complications and improve public health. Full article
(This article belongs to the Special Issue The Role of Nutrition in Metabolic Dysfunction-Associated Steatotic Liver Disease)
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