Patient-Centered Care for Enhancing Health-Related Quality of Life: Integrating Clinical, Behavioral, and Social Determinants of Health

A special issue of Healthcare (ISSN 2227-9032).

Deadline for manuscript submissions: 30 July 2026 | Viewed by 2682

Special Issue Editor


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Guest Editor
Center of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia
Interests: clinical nutrition; public health nutrition; nutritional interventions; oncology; tumor biology; cancer survivorship; urology; urological disease management; health outcomes

Special Issue Information

Dear Colleagues,

It is our pleasure to invite you to contribute to a Special Issue which aims to illuminate the intricate and dynamic interplay of diverse determinants shaping health-related quality of life (HRQoL) within the evolving paradigm of patient-centered care. As healthcare systems transition toward more integrative, holistic models, the convergence of clinical practice, lifestyle factors, and broader social environment provides a unique avenue to elevate patient well-being and optimize outcomes.

This Special Issue aims to showcase a broad spectrum of healthcare perspectives, aligning with the goals of Healthcare by spotlighting patient-centered approaches that transcend traditional boundaries of clinical care. We welcome innovative contributions that elucidate how multidimensional strategies—spanning clinical, behavioral, and social spheres—can enhance care delivery and foster equity, and enrich the patient experience across varied healthcare settings. By cultivating an interdisciplinary dialogue, this Special Issue aspires to promote the dissemination and critical appraisal of current knowledge, while unveiling emerging trends and navigating the complexities, challenges, and transformative shifts in the pursuit of enhanced HRQoL.

We encourage submissions of original research articles and comprehensive reviews that explore, but are not limited to, the following themes:

- Multidisciplinary approaches to patient-centered care for disease management;

- The influence of social determinants on HRQoL across diverse populations;

- The impact of integrated care models on HRQoL outcomes;

- Health equity and access in patient-centered care;

- Policy implications for integrating clinical, behavioral, and social determinants of health.

We eagerly anticipate your contributions, which will catalyze fresh perspectives, inspire progress, fuel innovation, and redefine the trajectory of advancements in healthcare delivery.

Dr. Milica Zeković
Guest Editor

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Keywords

  • health-related quality of life
  • patient-centered care
  • social determinants of health
  • multidisciplinary care
  • healthcare innovation
  • health outcomes
  • personalized care

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Published Papers (3 papers)

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Research

18 pages, 1297 KB  
Article
Feasibility of a Person-Centred Nursing Model Targeting Patient and Family Caregiver Needs in Allogeneic Haematopoietic Stem Cell Transplantation
by Annika Malmborg Kisch, Linda V. Eriksson, Anna O’Sullivan, Aida Shahriari, Karin Bergkvist, Carina Lundh Hagelin and Jeanette Winterling
Healthcare 2025, 13(19), 2463; https://doi.org/10.3390/healthcare13192463 - 28 Sep 2025
Viewed by 242
Abstract
Background/Objectives: Undergoing intensive cancer treatment, such as allogeneic haematopoietic stem cell transplantation, challenges the entire life situation of patients and their family caregivers. A prerequisite for effective care is that interventions are tailored to the unique circumstances of each individual. The aim [...] Read more.
Background/Objectives: Undergoing intensive cancer treatment, such as allogeneic haematopoietic stem cell transplantation, challenges the entire life situation of patients and their family caregivers. A prerequisite for effective care is that interventions are tailored to the unique circumstances of each individual. The aim of this study was to examine the feasibility of a developed person-centred nursing model in this context. Methods: The nursing model involves systematic use of conversation tools with subsequent conversations to assess and address the needs of patients (two tools) and their family caregivers (one tool). Patients, family caregivers and registered nurses from two Swedish stem cell transplantation centres testing the model were included. Data to measure practicality were gathered from the tools and documented conversations, while acceptability was assessed from the interviews. Results: 36 patients, 32 family caregivers and 16 registered nurses participated. 67–94% of the patients and 94% of the family caregivers completed the tools. 78–97% of the subsequent conversations were conducted as planned. 78% of the patients and registered nurses were positive about one of the patient tools, while 41% were positive about the other patient tool. 95% of the family caregivers and registered nurses were positive about the family caregiver tool. Most participants considered that the systematic use of tools helped to structure a holistic needs assessment. Conclusions: This feasibility study indicates that most components of our nursing model are practical, acceptable and support registered nurses when conducting person-centred nursing. With further development, the model has the potential to enhance the quality of care and support within the cancer context. Full article
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14 pages, 427 KB  
Article
Factors Associated with Decisional Regret After Shared Decision Making for Patients Undergoing Total Knee Arthroplasty
by Yu-Chieh Lo, Yu-Pin Chen, Hui En Lin, Wei-Chun Chang, Wei-Pin Ho, Jia-Pei Jang and Yi-Jie Kuo
Healthcare 2025, 13(13), 1597; https://doi.org/10.3390/healthcare13131597 - 3 Jul 2025
Viewed by 1017
Abstract
Introduction: Total knee arthroplasty (TKA) is a treatment for knee pain, but some patients are not satisfied with their outcomes. Utilizing shared decision making (SDM) can lead to better decisions, satisfaction, and fewer regrets. However, healthcare professionals have little knowledge of risk factors [...] Read more.
Introduction: Total knee arthroplasty (TKA) is a treatment for knee pain, but some patients are not satisfied with their outcomes. Utilizing shared decision making (SDM) can lead to better decisions, satisfaction, and fewer regrets. However, healthcare professionals have little knowledge of risk factors for regret. The aim of this study is to evaluate decisional regret using the Decision Regret Scale (DRS) after primary TKA among patients who engaged in SDM. Method: A total of 118 patients who underwent TKA surgery between March 2020 and May 2022 participated in this study, and they were able to reflect on their outcomes. The primary outcome was decisional regret assessed using the DRS, and the secondary outcome was post-operative pain at a three-month follow-up, measured using the Lequesne Index. Result: The study found that 49% of the patients reported no regret, 25% reported mild regret, and 26% reported moderate-to-severe regret. There was a significant correlation between greater levels of decision regret and a higher three-month Lequesne Index. Post-operative pain and post-operative mobility status and the range of motion of the knee joint were also strongly correlated. Conclusion: The study found that more than half of the patients undergoing primary TKAs experienced regret even following SDM counseling. Regret levels were associated with higher post-operative pain and poorer mobility. This underscores the importance of informing patients about potential adverse effects of TKA to manage their expectations and reduce regret in future SDM interviews. Practice implications: This study incorporated patient perspectives through their direct engagement in the SDM process prior to surgery. Patients participated in the design of the SDM framework, which included educational pamphlets and structured interviews to assess their values and preferences. Their involvement ensured that the SDM procedure was tailored to patient-centered outcomes. Furthermore, the follow-up assessments were conducted with patients to evaluate decisional regret and post-operative outcomes, providing valuable insights into the effectiveness of the SDM process. By actively participating in the research through decision making and outcome reflection, the patients contributed to the understanding of factors influencing decisional regret after undergoing TKA. Full article
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22 pages, 5529 KB  
Article
From Perception to Action: Air Pollution Awareness and Behavioral Adjustments in Pregnant Women in Serbia
by Ana Susa, Milica Zekovic, Dragana Davidovic, Katarina Paunovic, Vera Kujundzic, Sladjana Mihajlovic and Ljiljana Bogdanovic
Healthcare 2025, 13(12), 1475; https://doi.org/10.3390/healthcare13121475 - 19 Jun 2025
Viewed by 865
Abstract
In regions with sustained air pollution, the adoption of protective health behaviors is critical, particularly among pregnant women—a population marked by physiological vulnerability and heightened receptivity to preventive guidance. Understanding and supporting patient-driven behavioral change requires attention to individual perception and awareness, which [...] Read more.
In regions with sustained air pollution, the adoption of protective health behaviors is critical, particularly among pregnant women—a population marked by physiological vulnerability and heightened receptivity to preventive guidance. Understanding and supporting patient-driven behavioral change requires attention to individual perception and awareness, which are shaped by socio-economic and spatial factors, as well as access to credible information. Objectives: This study investigates how pregnant women in Serbia perceive air quality, identifies determinants that influence these perceptions, and evaluates the extent and nature of behavioral adaptations undertaken to mitigate exposure-related risks. Methods: A cross-sectional survey was conducted among 279 pregnant women using a structured, researcher-administered questionnaire. Collected data included demographic and psychosocial variables, air quality perceptions, self-reported health effects, and behavioral responses. Residential proximity to land-use attributes was assessed using GIS-based spatial analysis. Results: Most participants perceived air quality as poor (68.8%), primarily informed by unofficial sources such as mobile applications and social media. Living close to continuous urban fabric (OR = 0.180, 95% CI: 0.059–0.558, p = 0.003) and water (OR = 0.306, 95% CI: 0.127–0.738, p = 0.008) was associated with poorer perceptions, while proximity to forests (OR = 2.938, 95% CI: 1.323–6.525, p = 0.008) correlated with more favorable assessments. Despite prevalent concern, around half of respondents (50.2%) reported no behavioral modifications. Importantly, none had received guidance from healthcare professionals on the topic. Conclusions: These findings highlight critical gaps in environmental health literacy and provider engagement. Integrating tailored communication and behavioral support in existing prenatal counseling could advance health-related quality of life in this vulnerable population. Full article
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